Common variable immunodeficiency (CVI) is a heterogenous syndrome characterized by defective antibody formation, resulting in abnormally low serum immunoglobulin levels. Clinical presentation usually includes recurrent infections of the respiratory tract, mostly induced by capsular bacteria. Patients are also highly prone to Giardia lamblia infections and related gastrointestinal disorders, as well as to a variety of autoimmune diseases which appear in approximately 20% of them. In addition, CVI can be frequently associated with a non-Hodgkin lymphoma or gastric carcinoma. In spite of its relatively frequent occurrence, the pathogenesis of CVI still remains poorly defined. An overview of the syndrome is published in this issue (pages 616-622). The Authors experience (18 cases during last five years) is here reported.
|Translated title of the contribution||Common variable immunodeficiency. Report of 18 cases|
|Number of pages||3|
|Journal||Recenti Progressi in Medicina|
|Publication status||Published - Dec 1996|
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