Common variants at five new loci associated with early-onset inflammatory bowel disease

Marcin Imielinski, Robert N. Baldassano, Anne Griffiths, Richard K. Russell, Vito Annese, Marla Dubinsky, Subra Kugathasan, Jonathan P. Bradfield, Thomas D. Walters, Patrick Sleiman, Cecilia E. Kim, Aleixo Muise, Kai Wang, Joseph T. Glessner, Shehzad Saeed, Haitao Zhang, Edward C. Frackelton, Cuiping Hou, James H. Flory, George OtienoRosetta M. Chiavacci, Robert Grundmeier, Massimo Castro, Anna Latiano, Bruno Dallapiccola, Joanne Stempak, Debra J. Abrams, Kent Taylor, Dermot McGovern, Melvin B. Heyman, George D. Ferry, Barbara Kirschner, Jessica Lee, Jonah Essers, Richard Grand, Michael Stephens, Arie Levine, David Piccoli, Johan Van Limbergen, Salvatore Cucchiara, Dimitri S. Monos, Stephen L. Guthery, Lee Denson, David C. Wilson, Struan F A Grant, Mark Daly, Mark S. Silverberg, Jack Satsangi, Hakon Hakonarson

Research output: Contribution to journalArticle

Abstract

The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 × 10 9), 22q12 (rs2412973, P = 1.55 × 10 9), 10q22 (rs1250550, P = 5.63 × 10 9), 2q37 (rs4676410, P = 3.64 × 10 8) and 19q13.11 (rs10500264, P = 4.26 × 10 10). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early-and adult-onset IBD.

Original languageEnglish
Pages (from-to)1335-1340
Number of pages6
JournalNature Genetics
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 2009

ASJC Scopus subject areas

  • Genetics

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    Imielinski, M., Baldassano, R. N., Griffiths, A., Russell, R. K., Annese, V., Dubinsky, M., Kugathasan, S., Bradfield, J. P., Walters, T. D., Sleiman, P., Kim, C. E., Muise, A., Wang, K., Glessner, J. T., Saeed, S., Zhang, H., Frackelton, E. C., Hou, C., Flory, J. H., ... Hakonarson, H. (2009). Common variants at five new loci associated with early-onset inflammatory bowel disease. Nature Genetics, 41(12), 1335-1340. https://doi.org/10.1038/ng.489