Common variants in FOXP1 are associated with generalized vitiligo

Ying Jin, Stanca A. Birlea, Pamela R. Fain, Christina M. Mailloux, Sheri L. Riccardi, Katherine Gowan, Paulene J. Holland, Dorothy C. Bennett, Margaret R. Wallace, Wayne T. McCormack, E. Helen Kemp, David J. Gawkrodger, Anthony P. Weetman, Mauro Picardo, Giovanni Leone, Alain Taĩeb, Thomas Jouary, Khaled Ezzedine, Nanny Van Geel, Jo LambertAndreas Overbeck, Richard A. Spritz

Research output: Contribution to journalArticle

Abstract

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10 8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10-7).

Original languageEnglish
Pages (from-to)576-578
Number of pages3
JournalNature Genetics
Volume42
Issue number7
DOIs
Publication statusPublished - Jul 2010

ASJC Scopus subject areas

  • Genetics

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    Jin, Y., Birlea, S. A., Fain, P. R., Mailloux, C. M., Riccardi, S. L., Gowan, K., Holland, P. J., Bennett, D. C., Wallace, M. R., McCormack, W. T., Kemp, E. H., Gawkrodger, D. J., Weetman, A. P., Picardo, M., Leone, G., Taĩeb, A., Jouary, T., Ezzedine, K., Van Geel, N., ... Spritz, R. A. (2010). Common variants in FOXP1 are associated with generalized vitiligo. Nature Genetics, 42(7), 576-578. https://doi.org/10.1038/ng.602