TY - JOUR
T1 - Common variants in UMOD associate with urinary uromodulin levels
T2 - A meta-analysis
AU - Olden, Matthias
AU - Corre, Tanguy
AU - Hayward, Caroline
AU - Toniolo, Daniela
AU - Ulivi, Sheila
AU - Gasparini, Paolo
AU - Pistis, Giorgio
AU - Hwang, Shih Jen
AU - Bergmann, Sven
AU - Campbell, Harry
AU - Cocca, Massimiliano
AU - Gandin, Ilaria
AU - Girotto, Giorgia
AU - Glaudemans, Bob
AU - Hastie, Nicholas D.
AU - Loffing, Johannes
AU - Polasek, Ozren
AU - Rampoldi, Luca
AU - Rudan, Igor
AU - Sala, Cinzia
AU - Traglia, Michela
AU - Vollenweider, Peter
AU - Vuckovic, Dragana
AU - Youhanna, Sonia
AU - Weber, Julien
AU - Wright, Alan F.
AU - Kutalik, Zoltán
AU - Bochud, Murielle
AU - Fox, Caroline S.
AU - Devuyst, Olivier
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are associated with renal function, and urinary uromodulin levels may be a biomarker for kidney disease. However, the genetic factors regulating uromodulin excretion are unknown.We conducted ameta-analysis of urinary uromodulin levels to identify associatedcommon genetic variants in the general population.We included10,884 individuals of European descent from three genetic isolates and three urban cohorts. Each study measured uromodulin indexed to creatinine and conducted linear regression analysis of approximately 2.5 million single nucleotide polymorphisms using an additive model.Wealso tested whether variants in genes expressed in the thick ascending limb associate with uromodulin levels. rs12917707, located near UMOD and previously associated with renal function and CKD, had the strongest association with urinary uromodulin levels (P
AB - Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are associated with renal function, and urinary uromodulin levels may be a biomarker for kidney disease. However, the genetic factors regulating uromodulin excretion are unknown.We conducted ameta-analysis of urinary uromodulin levels to identify associatedcommon genetic variants in the general population.We included10,884 individuals of European descent from three genetic isolates and three urban cohorts. Each study measured uromodulin indexed to creatinine and conducted linear regression analysis of approximately 2.5 million single nucleotide polymorphisms using an additive model.Wealso tested whether variants in genes expressed in the thick ascending limb associate with uromodulin levels. rs12917707, located near UMOD and previously associated with renal function and CKD, had the strongest association with urinary uromodulin levels (P
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U2 - 10.1681/ASN.2013070781
DO - 10.1681/ASN.2013070781
M3 - Article
C2 - 24578125
AN - SCOPUS:84910148385
VL - 25
SP - 1869
EP - 1882
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
SN - 1046-6673
IS - 8
ER -