CoMon variants at TRAF3IP2 are aSociated with susceptibility to psoriatic arthritis and psoriasis

Ulrike Hüffmeier, Steffen Uebe, Arif B. Ekici, John Bowes, Emiliano Giardina, Eleanor Korendowych, Kristina Juneblad, Maria Apel, Ross McManus, Pauline Ho, Ian N. Bruce, Anthony W. Ryan, Frank Behrens, Jesús Lascorz, Beate Böhm, Heiko Traupe, Jörg LohmaN, Christian Gieger, Heinz Erich Wichman, Christine HeroldMichael Steffens, Lars Klareskog, Thomas F. Wienker, Oliver FitzGerald, Gerd Marie Alenius, Neil J. McHugh, Giuseppe Novelli, Harald Burkhardt, Ane Barton, André Reis

Research output: Contribution to journalArticle

Abstract

Psoriatic arthritis (PsA) is an inflaMatory joint disease that is distinct from other chronic arthritides and which is frequently aCompanied by psoriasis vulgaris (PsV) and seronegativity for rheumatoid factor. We conducted a genome-wide aSociation study in 609 German individuals with PsA (cases) and 990 controls with replication in 6 European cohorts including a total of 5,488 individuals. We replicated PsA aSociations at HLA-C and IL12B and identified a new aSociation at TRAF3IP2 (rs13190932, P = 8.56-10-17). TRAF3IP2 was also aSociated with PsV in a German cohort including 2,040 individuals (rs13190932, P = 1.95-10-3). Sequencing of the exons of TRAF3IP2 identified a coding variant (p.Asp10Asn, rs33980500) as the most significantly aSociated SNP (P = 1.13-10-20, oDs ratio = 1.95). Functional aSays showed reduced binding of this TRAF3IP2 variant to TRAF6, suGesting altered modulation of iMunoregulatory signals through altered TRAF interactions as a new and shared pathway for PsA and PsV.

Original languageEnglish
Pages (from-to)996-999
Number of pages4
JournalNature Genetics
Volume42
Issue number11
DOIs
Publication statusPublished - Nov 2010

ASJC Scopus subject areas

  • Genetics

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    Hüffmeier, U., Uebe, S., Ekici, A. B., Bowes, J., Giardina, E., Korendowych, E., Juneblad, K., Apel, M., McManus, R., Ho, P., Bruce, I. N., Ryan, A. W., Behrens, F., Lascorz, J., Böhm, B., Traupe, H., LohmaN, J., Gieger, C., Wichman, H. E., ... Reis, A. (2010). CoMon variants at TRAF3IP2 are aSociated with susceptibility to psoriatic arthritis and psoriasis. Nature Genetics, 42(11), 996-999. https://doi.org/10.1038/ng.688