Comorbidities frequency in Takotsubo syndrome: an international collaborative systematic review including 1109 patients

Francesco Pelliccia, Guido Parodi, Cesare Greco, David Antoniucci, Roman Brenner, Eduardo Bossone, Luca Cacciotti, Alessandro Capucci, Rodolfo Citro, Clément Delmas, Federico Guerra, Costin N. Ionescu, Olivier Lairez, Maiteder Larrauri-Reyes, Pil H yung Lee, Nicolas Mansencal, Giuseppe Marazzi, Christos G. Mihos, Olivier Morel, Holger M. NefIvan J. Nunez Gil, Ilaria Passaseo, Andres M. Pineda, Giuseppe Rosano, Orlando Santana, Franziska Schneck, Bong G un Song, Jae Kwan Song, Andrew W. Teh, Patompong Ungprasert, Alberto Valbusa, Andreas Wahl, Tetsuro Yoshida, Carlo Gaudio, Juan C arlos Kaski

Research output: Contribution to journalArticle

Abstract

BACKGROUND: To identify predisposing factors that can result in the onset of takotsubo syndrome, we performed an international, collaborative systematic review focusing on clinical characteristics and comorbidities of patients with takotsubo syndrome.

METHODS: We searched and reviewed cited references up to August 2013 to identify relevant studies. Corresponding authors of selected studies were contacted and asked to provide additional quantitative details. Data from each study were extracted by 2 independent reviewers. The cumulative prevalence of presenting features and comorbidities was assessed. Nineteen studies whose authors sent the requested information were included in the systematic review, with a total of 1109 patients (951 women; mean age, 59-76 years). Evaluation of risk factors showed that obesity was present in 17% of patients (range, 2%-48%), hypertension in 54% (range, 27%-83%), dyslipidemia in 32% (range, 7%-59%), diabetes in 17% (range, 4%-34%), and smoking in 22% (range, 6%-49%). Emotional stressors preceded takotsubo syndrome in 39% of patients and physical stressors in 35%. The most common comorbidities were psychological disorders (24%; range, 0-49%), pulmonary diseases (15%; range, 0-22%), and malignancies (10%; range, 4%-29%). Other common associated disorders were neurologic diseases (7%; range, 0-22%), chronic kidney disease (7%; range, 2%-27%), and thyroid diseases (6%; range, 0-37%).

CONCLUSIONS: Patients with takotsubo syndrome have a relevant prevalence of cardiovascular risk factors and associated comorbidities. Such of associations needs to be evaluated in further studies.

Original languageEnglish
JournalAmerican Journal of Medicine
Volume128
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Takotsubo Cardiomyopathy
Comorbidity
Thyroid Diseases
Dyslipidemias
Nervous System Diseases
Chronic Renal Insufficiency
Causality
Lung Diseases
Obesity
Smoking
Psychology
Hypertension
Neoplasms

Keywords

  • Acute left ventricular dysfunction
  • Apical ballooning syndrome
  • Cardiomyopathy
  • Takotsubo cardiomyopathy
  • Takotsubo syndrome

ASJC Scopus subject areas

  • Medicine(all)

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Comorbidities frequency in Takotsubo syndrome : an international collaborative systematic review including 1109 patients. / Pelliccia, Francesco; Parodi, Guido; Greco, Cesare; Antoniucci, David; Brenner, Roman; Bossone, Eduardo; Cacciotti, Luca; Capucci, Alessandro; Citro, Rodolfo; Delmas, Clément; Guerra, Federico; Ionescu, Costin N.; Lairez, Olivier; Larrauri-Reyes, Maiteder; Lee, Pil H yung; Mansencal, Nicolas; Marazzi, Giuseppe; Mihos, Christos G.; Morel, Olivier; Nef, Holger M.; Nunez Gil, Ivan J.; Passaseo, Ilaria; Pineda, Andres M.; Rosano, Giuseppe; Santana, Orlando; Schneck, Franziska; Song, Bong G un; Song, Jae Kwan; Teh, Andrew W.; Ungprasert, Patompong; Valbusa, Alberto; Wahl, Andreas; Yoshida, Tetsuro; Gaudio, Carlo; Kaski, Juan C arlos.

In: American Journal of Medicine, Vol. 128, No. 6, 01.06.2015.

Research output: Contribution to journalArticle

Pelliccia, F, Parodi, G, Greco, C, Antoniucci, D, Brenner, R, Bossone, E, Cacciotti, L, Capucci, A, Citro, R, Delmas, C, Guerra, F, Ionescu, CN, Lairez, O, Larrauri-Reyes, M, Lee, PHY, Mansencal, N, Marazzi, G, Mihos, CG, Morel, O, Nef, HM, Nunez Gil, IJ, Passaseo, I, Pineda, AM, Rosano, G, Santana, O, Schneck, F, Song, BGU, Song, JK, Teh, AW, Ungprasert, P, Valbusa, A, Wahl, A, Yoshida, T, Gaudio, C & Kaski, JCA 2015, 'Comorbidities frequency in Takotsubo syndrome: an international collaborative systematic review including 1109 patients', American Journal of Medicine, vol. 128, no. 6. https://doi.org/10.1016/j.amjmed.2015.01.016
Pelliccia, Francesco ; Parodi, Guido ; Greco, Cesare ; Antoniucci, David ; Brenner, Roman ; Bossone, Eduardo ; Cacciotti, Luca ; Capucci, Alessandro ; Citro, Rodolfo ; Delmas, Clément ; Guerra, Federico ; Ionescu, Costin N. ; Lairez, Olivier ; Larrauri-Reyes, Maiteder ; Lee, Pil H yung ; Mansencal, Nicolas ; Marazzi, Giuseppe ; Mihos, Christos G. ; Morel, Olivier ; Nef, Holger M. ; Nunez Gil, Ivan J. ; Passaseo, Ilaria ; Pineda, Andres M. ; Rosano, Giuseppe ; Santana, Orlando ; Schneck, Franziska ; Song, Bong G un ; Song, Jae Kwan ; Teh, Andrew W. ; Ungprasert, Patompong ; Valbusa, Alberto ; Wahl, Andreas ; Yoshida, Tetsuro ; Gaudio, Carlo ; Kaski, Juan C arlos. / Comorbidities frequency in Takotsubo syndrome : an international collaborative systematic review including 1109 patients. In: American Journal of Medicine. 2015 ; Vol. 128, No. 6.
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AU - Pelliccia, Francesco

AU - Parodi, Guido

AU - Greco, Cesare

AU - Antoniucci, David

AU - Brenner, Roman

AU - Bossone, Eduardo

AU - Cacciotti, Luca

AU - Capucci, Alessandro

AU - Citro, Rodolfo

AU - Delmas, Clément

AU - Guerra, Federico

AU - Ionescu, Costin N.

AU - Lairez, Olivier

AU - Larrauri-Reyes, Maiteder

AU - Lee, Pil H yung

AU - Mansencal, Nicolas

AU - Marazzi, Giuseppe

AU - Mihos, Christos G.

AU - Morel, Olivier

AU - Nef, Holger M.

AU - Nunez Gil, Ivan J.

AU - Passaseo, Ilaria

AU - Pineda, Andres M.

AU - Rosano, Giuseppe

AU - Santana, Orlando

AU - Schneck, Franziska

AU - Song, Bong G un

AU - Song, Jae Kwan

AU - Teh, Andrew W.

AU - Ungprasert, Patompong

AU - Valbusa, Alberto

AU - Wahl, Andreas

AU - Yoshida, Tetsuro

AU - Gaudio, Carlo

AU - Kaski, Juan C arlos

PY - 2015/6/1

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N2 - BACKGROUND: To identify predisposing factors that can result in the onset of takotsubo syndrome, we performed an international, collaborative systematic review focusing on clinical characteristics and comorbidities of patients with takotsubo syndrome.METHODS: We searched and reviewed cited references up to August 2013 to identify relevant studies. Corresponding authors of selected studies were contacted and asked to provide additional quantitative details. Data from each study were extracted by 2 independent reviewers. The cumulative prevalence of presenting features and comorbidities was assessed. Nineteen studies whose authors sent the requested information were included in the systematic review, with a total of 1109 patients (951 women; mean age, 59-76 years). Evaluation of risk factors showed that obesity was present in 17% of patients (range, 2%-48%), hypertension in 54% (range, 27%-83%), dyslipidemia in 32% (range, 7%-59%), diabetes in 17% (range, 4%-34%), and smoking in 22% (range, 6%-49%). Emotional stressors preceded takotsubo syndrome in 39% of patients and physical stressors in 35%. The most common comorbidities were psychological disorders (24%; range, 0-49%), pulmonary diseases (15%; range, 0-22%), and malignancies (10%; range, 4%-29%). Other common associated disorders were neurologic diseases (7%; range, 0-22%), chronic kidney disease (7%; range, 2%-27%), and thyroid diseases (6%; range, 0-37%).CONCLUSIONS: Patients with takotsubo syndrome have a relevant prevalence of cardiovascular risk factors and associated comorbidities. Such of associations needs to be evaluated in further studies.

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KW - Acute left ventricular dysfunction

KW - Apical ballooning syndrome

KW - Cardiomyopathy

KW - Takotsubo cardiomyopathy

KW - Takotsubo syndrome

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