Comorbidities in elderly patients with glioblastoma: A field-practice study

Veronica Villani, Antonio Tanzilli, Stefano M. Telera, Irene Terrenato, Antonello Vidiri, Alessandra Fabi, Chiara Zucchella, Carmine M. Carapella, Laura Marucci, Beatrice Casini, Mariantonia Carosi, Piero M. Oppido, Andrea Pace

Research output: Contribution to journalArticlepeer-review


Aim: This single-center study evaluated the effect of comorbidities on progression-free and overall survival in elderly patients with glioblastoma multiforme (GBM). Patients & methods: Comorbid conditions were identified in each patient with the modified version of the cumulative illness rating scale (CIRS). Results: Total of 118 patients with GBM were enrolled. An age of >75 years at diagnosis, high CIRS, comorbidity index and performance status play a predictive role on survival. Conclusion: Comorbidities play an important prognostic role in elderly patients with GBM, a factor too often neglected in clinical practice. If the prognostic role of comorbidity measured by CIRS on outcome will be confirmed, it would be interesting to add it in the algorithm for treatment choice in elderly GBM patients.

Original languageEnglish
Pages (from-to)841-850
Number of pages10
JournalFuture Oncology
Issue number8
Publication statusPublished - Mar 2019


  • comorbidities
  • elderly
  • glioblastoma
  • progression-free survival
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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