Comorbidities of chronic obstructive pulmonary disease

Andrea Corsonello, Raffaele Antonelli Incalzi, Riccardo Pistelli, Claudio Pedone, Silvia Bustacchini, Fabrizia Lattanzio

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Purpose of review: Defining the nature of the association between chronic obstructive pulmonary disease (COPD) and other chronic conditions is of primary importance to improve the health status of COPD patients through the optimal care of comorbidities. We aimed at providing a reasoned guide to understand, recognize and treat comorbidity of COPD with the perspective of shifting from comorbidity to multimorbidity. Recent findings: Select comorbidities, such as atherosclerotic disease, depression, chronic kidney disease, cognitive impairment, obstructive sleep apnea syndrome, lung cancer, osteoporosis, diabetes, heart failure, sarcopenia, aortic aneurysm, arrhythmias and pulmonary embolism are highly prevalent among older COPD patients. Several concerns may affect the management of older COPD patients with comorbidity (e.g. the use of β-blockers in patients with COPD and cardiovascular diseases or concerns about the cardiovascular safety of inhaled COPD drugs). Summary: Evidence suggests that systemic inflammation may be the link between COPD and comorbidities, but this issue is still debated. Whatever the mechanism underlying comorbidities in COPD may be, it has an important clinical, prognostic and therapeutic impact. Nevertheless, clinical practice guidelines do not take into account comorbidities in their recommendations. Additionally, clinical trials investigating COPD treatment in the context of multimorbidity and considering geriatric outcomes are also distinctly lacking.

Original languageEnglish
JournalCurrent Opinion in Pulmonary Medicine
Volume17
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Dec 2011

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Chronic Obstructive Pulmonary Disease
Comorbidity
Sarcopenia
Aortic Aneurysm
Obstructive Sleep Apnea
Pulmonary Embolism
Chronic Renal Insufficiency
Practice Guidelines
Geriatrics
Health Status
Osteoporosis
Cardiac Arrhythmias
Lung Neoplasms
Cardiovascular Diseases
Heart Failure
Clinical Trials
Depression
Inflammation
Safety
Therapeutics

Keywords

  • comorbidity
  • COPD
  • elderly
  • guidelines

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Comorbidities of chronic obstructive pulmonary disease. / Corsonello, Andrea; Antonelli Incalzi, Raffaele; Pistelli, Riccardo; Pedone, Claudio; Bustacchini, Silvia; Lattanzio, Fabrizia.

In: Current Opinion in Pulmonary Medicine, Vol. 17, No. SUPPL. 1, 12.2011.

Research output: Contribution to journalArticle

Corsonello, Andrea ; Antonelli Incalzi, Raffaele ; Pistelli, Riccardo ; Pedone, Claudio ; Bustacchini, Silvia ; Lattanzio, Fabrizia. / Comorbidities of chronic obstructive pulmonary disease. In: Current Opinion in Pulmonary Medicine. 2011 ; Vol. 17, No. SUPPL. 1.
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