Comorbilità e politerapia: Il rischio iatrogeno nell'anziano

Translated title of the contribution: Comorbidity and polypharmacy in the elderly

Alberto Pilotto, C. Scarcelli, V. Niro, G. Pepe, D. Vitale, P. Cascavilla, M. Franceschi

Research output: Contribution to journalArticlepeer-review


The prevalence of both adverse drug reactions (ADR) and adverse drug events (ADE) increases with advancing age. High drug use, pharmacokinetic modifications and failure of specific systems, i.e. renal, gastrointestinal and central nervous system, are the main reasons of the high iatrogenic risk in old age. The most frequent severe ADRs in the elderly are gastrointestinal, metabolic and haemorrhagic. These ADRs are mainly due to the use of NSAIDs, aspirin and other antiplatelet drugs, anticoagulants, diuretics, anti-hypertensives, benzodiazepines, antidepressants. The available strategies for preventing ADR and ADE in old age are avoid inappropriate prescriptions, use low dosages and less damaging drug classes, use protective drugs, education of physician, care givers and patients.

Translated title of the contributionComorbidity and polypharmacy in the elderly
Original languageItalian
Pages (from-to)57-62
Number of pages6
JournalGiornale di Gerontologia
Issue numberSUPPL. 1
Publication statusPublished - Feb 2005

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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