Abstract
To assess the comparability of ultrasonographic (US) subcutaneous fat thickness (SFT) measurements in comparison with computed tomography (CT) at reference points (RPs) representative of HIV related adipose redistribution syndrome (HARS) in patients treated with antiretrovirals. US and CT measurements were compared in nine patients with clinical reports of HARS. We obtained the best resolution of facial (at deepest point of Bichat pad), brachial (in the dorsal face of arm) and crural SFT (at mid thigh) by means of minimal transducer pressures avoiding potential biases such as stand off pads pressure on the skin and artefacts due to too abundant quantity of gel. CT scans were obtained in the same RP where US measurements were performed such as identified by means of metallic skin markers. Median US measurement of facial SFT was 8.8 mm (95% CI: 3.1 to 13.4), 3.95 mm (95% CI: 2.62 to 5.84) for brachial SFT and 4 mm (95% CI: 3.4 to 9.4) for crural SFT. Median CT assessments of facial SFT was 8.7 mm (95% CI: 3.5 to 13.5), 4.2 mm (95% CI: 2.6 to 5.88) for brachial SFT and 5 mm (95% CI: 3.9 to 10.3) for crural SFT, with no significant difference at each RP. A linear regression showed good CT/US comparability at each RP, with no significant deviation from linearity (p > 0.10). US shows to be highly comparable with CT, excluding invaliding biases as the transducer pressure on the skin. Given the proven efficacy on the HARS assessments, if well standardized, US could be a reliable method, simpler than CT in the management of body fat changes related to HARS. (E-mail: steinman@imaging.robarts.ca).
| Original language | English |
|---|---|
| Pages (from-to) | 1043-1048 |
| Number of pages | 6 |
| Journal | Ultrasound in Medicine and Biology |
| Volume | 34 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2008 |
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Keywords
- Antiretrovirals
- Body fat changes
- HIV infection
- Lipodystrophy
- Ultrasonography
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Comparability of Echographic and Tomographic Assessments of Body Fat Changes Related to the HIV Associated Adipose Redistribution Syndrome (HARS) in Antiretroviral Treated Patients. / Gulizia, Rosario; Vercelli, Alessandro; Gervasoni, Cristina; Uglietti, Alessia; Ortu, Massimiliano; Ferraioli, Giovanna; Galli, Massimo; Filice, Carlo.
In: Ultrasound in Medicine and Biology, Vol. 34, No. 7, 07.2008, p. 1043-1048.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparability of Echographic and Tomographic Assessments of Body Fat Changes Related to the HIV Associated Adipose Redistribution Syndrome (HARS) in Antiretroviral Treated Patients
AU - Gulizia, Rosario
AU - Vercelli, Alessandro
AU - Gervasoni, Cristina
AU - Uglietti, Alessia
AU - Ortu, Massimiliano
AU - Ferraioli, Giovanna
AU - Galli, Massimo
AU - Filice, Carlo
PY - 2008/7
Y1 - 2008/7
N2 - To assess the comparability of ultrasonographic (US) subcutaneous fat thickness (SFT) measurements in comparison with computed tomography (CT) at reference points (RPs) representative of HIV related adipose redistribution syndrome (HARS) in patients treated with antiretrovirals. US and CT measurements were compared in nine patients with clinical reports of HARS. We obtained the best resolution of facial (at deepest point of Bichat pad), brachial (in the dorsal face of arm) and crural SFT (at mid thigh) by means of minimal transducer pressures avoiding potential biases such as stand off pads pressure on the skin and artefacts due to too abundant quantity of gel. CT scans were obtained in the same RP where US measurements were performed such as identified by means of metallic skin markers. Median US measurement of facial SFT was 8.8 mm (95% CI: 3.1 to 13.4), 3.95 mm (95% CI: 2.62 to 5.84) for brachial SFT and 4 mm (95% CI: 3.4 to 9.4) for crural SFT. Median CT assessments of facial SFT was 8.7 mm (95% CI: 3.5 to 13.5), 4.2 mm (95% CI: 2.6 to 5.88) for brachial SFT and 5 mm (95% CI: 3.9 to 10.3) for crural SFT, with no significant difference at each RP. A linear regression showed good CT/US comparability at each RP, with no significant deviation from linearity (p > 0.10). US shows to be highly comparable with CT, excluding invaliding biases as the transducer pressure on the skin. Given the proven efficacy on the HARS assessments, if well standardized, US could be a reliable method, simpler than CT in the management of body fat changes related to HARS. (E-mail: steinman@imaging.robarts.ca).
AB - To assess the comparability of ultrasonographic (US) subcutaneous fat thickness (SFT) measurements in comparison with computed tomography (CT) at reference points (RPs) representative of HIV related adipose redistribution syndrome (HARS) in patients treated with antiretrovirals. US and CT measurements were compared in nine patients with clinical reports of HARS. We obtained the best resolution of facial (at deepest point of Bichat pad), brachial (in the dorsal face of arm) and crural SFT (at mid thigh) by means of minimal transducer pressures avoiding potential biases such as stand off pads pressure on the skin and artefacts due to too abundant quantity of gel. CT scans were obtained in the same RP where US measurements were performed such as identified by means of metallic skin markers. Median US measurement of facial SFT was 8.8 mm (95% CI: 3.1 to 13.4), 3.95 mm (95% CI: 2.62 to 5.84) for brachial SFT and 4 mm (95% CI: 3.4 to 9.4) for crural SFT. Median CT assessments of facial SFT was 8.7 mm (95% CI: 3.5 to 13.5), 4.2 mm (95% CI: 2.6 to 5.88) for brachial SFT and 5 mm (95% CI: 3.9 to 10.3) for crural SFT, with no significant difference at each RP. A linear regression showed good CT/US comparability at each RP, with no significant deviation from linearity (p > 0.10). US shows to be highly comparable with CT, excluding invaliding biases as the transducer pressure on the skin. Given the proven efficacy on the HARS assessments, if well standardized, US could be a reliable method, simpler than CT in the management of body fat changes related to HARS. (E-mail: steinman@imaging.robarts.ca).
KW - Antiretrovirals
KW - Body fat changes
KW - HIV infection
KW - Lipodystrophy
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=45949111105&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45949111105&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2007.12.010
DO - 10.1016/j.ultrasmedbio.2007.12.010
M3 - Article
C2 - 18308461
AN - SCOPUS:45949111105
VL - 34
SP - 1043
EP - 1048
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 7
ER -