TY - JOUR
T1 - Comparable frequency of hepatocellular carcinoma in cirrhosis of different aetiology
AU - Mandelli, Clara
AU - Fraquelli, Mirella
AU - Fargion, Silvia
AU - Barisani, Donatella
AU - Piperno, Alberto
AU - Braga, Mario
AU - Fracanzani, Anna L.
AU - Bodini, Paolo
AU - Aimo, Gianpiero
AU - Conte, Dario
PY - 1994
Y1 - 1994
N2 - Objective: To evaluate by multivariate analysis whether the risk of hepatocellular carcinoma (HCC) varies in cirrhosis of different aetiology. Design: Cohort study of patients monitored every 6 months by laboratory tests and ultrasonography. Setting: Three northern Italian hospitals. Patients: A total of 396 patients (285 men and 111 women; median age, 58 years) with cirrhosis (253 with Child’s class A and 143 class B or C) attributable to alcohol abuse, chronic infection by hepatitis B or non-A non-B virus (hepatitis C virus in 79% of patients) and iron overload due to genetic haemochromatosis, were followed for 1–245 months (median, 50 months). Methods:Cox’s regression model was used to evaluate sex, age, Child’s class, and aetiology of cirrhosis as independent risk factors for HCC; interactions between aetiologic factors were also considered. Results: During follow-up, 143 patients died and 63 developed HCC. The cumulative probability of remaining free of HCC was 90, 80 and 68% at 2, 6 and 10 years. Age 58 years or more (hazard ratio, 4.26 versus age <58 years; P<0.001) and Child’s class B or C (hazard ratio, 1.81 versus Child’s class A; P
AB - Objective: To evaluate by multivariate analysis whether the risk of hepatocellular carcinoma (HCC) varies in cirrhosis of different aetiology. Design: Cohort study of patients monitored every 6 months by laboratory tests and ultrasonography. Setting: Three northern Italian hospitals. Patients: A total of 396 patients (285 men and 111 women; median age, 58 years) with cirrhosis (253 with Child’s class A and 143 class B or C) attributable to alcohol abuse, chronic infection by hepatitis B or non-A non-B virus (hepatitis C virus in 79% of patients) and iron overload due to genetic haemochromatosis, were followed for 1–245 months (median, 50 months). Methods:Cox’s regression model was used to evaluate sex, age, Child’s class, and aetiology of cirrhosis as independent risk factors for HCC; interactions between aetiologic factors were also considered. Results: During follow-up, 143 patients died and 63 developed HCC. The cumulative probability of remaining free of HCC was 90, 80 and 68% at 2, 6 and 10 years. Age 58 years or more (hazard ratio, 4.26 versus age <58 years; P<0.001) and Child’s class B or C (hazard ratio, 1.81 versus Child’s class A; P
KW - Alcohol abuse
KW - Cirrhosis
KW - Genetic haemochromatosis
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - Hepatocellular carcinoma
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M3 - Article
AN - SCOPUS:0028088648
VL - 6
SP - 1129
EP - 1134
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 12
ER -