Comparable frequency of hepatocellular carcinoma in cirrhosis of different aetiology

Clara Mandelli, Mirella Fraquelli, Silvia Fargion, Donatella Barisani, Alberto Piperno, Mario Braga, Anna L. Fracanzani, Paolo Bodini, Gianpiero Aimo, Dario Conte

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate by multivariate analysis whether the risk of hepatocellular carcinoma (HCC) varies in cirrhosis of different aetiology. Design: Cohort study of patients monitored every 6 months by laboratory tests and ultrasonography. Setting: Three northern Italian hospitals. Patients: A total of 396 patients (285 men and 111 women; median age, 58 years) with cirrhosis (253 with Child’s class A and 143 class B or C) attributable to alcohol abuse, chronic infection by hepatitis B or non-A non-B virus (hepatitis C virus in 79% of patients) and iron overload due to genetic haemochromatosis, were followed for 1–245 months (median, 50 months). Methods:Cox’s regression model was used to evaluate sex, age, Child’s class, and aetiology of cirrhosis as independent risk factors for HCC; interactions between aetiologic factors were also considered. Results: During follow-up, 143 patients died and 63 developed HCC. The cumulative probability of remaining free of HCC was 90, 80 and 68% at 2, 6 and 10 years. Age 58 years or more (hazard ratio, 4.26 versus age <58 years; P<0.001) and Child’s class B or C (hazard ratio, 1.81 versus Child’s class A; P

Original languageEnglish
Pages (from-to)1129-1134
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number12
Publication statusPublished - 1994


  • Alcohol abuse
  • Cirrhosis
  • Genetic haemochromatosis
  • Hepatitis B virus
  • Hepatitis C virus
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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