Comparable outcomes between unrelated and related donors after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation in patients with high-risk multiple myeloma

Jean El-Cheikh, Roberto Crocchiolo, Jean Marie Boher, Sabine Furst, Anne Marie Stoppa, Patrick Ladaique, Catherine Faucher, Boris Calmels, Luca Castagna, Claude Lemarie, Jean Marc Schiano De Colella, Diane Coso, Reda Bouabdallah, Christian Chabannon, Didier Blaise

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to assess the results of allogeneic stem cell transplantation (allo-SCT) after reduced-intensity conditioning (RIC) from matched related donors (MRD) and unrelated donors (URD) in 40 patients with high-risk multiple myeloma (MM) in a single centre. Seventeen (43%) (Group 1) and 23 patients (57%) (Group 2) had URD and MRD, respectively. Thirty-nine patients (98%) received one or more autologous transplantation. The median follow-up was 22months (1-49). None of our patient experienced a graft rejection. The cumulative incidence of grade II-IV acute GVHD was higher (47%) for the URD vs. (17%) for the MRD (P=0.092). The cumulative incidence of chronic GVHD was no different between the two groups (24% vs. 30%, respectively). At 2yr, the TRM probabilities were lower in the unrelated group 12% vs. 22% in the related group (P=0.4). Also at 2yrs, for patients receiving unrelated transplantation overall and progression-free survivals, 59% and 42%, respectively compared to patients with related donor transplantation, 66% and 44% (P=0.241). In conclusion, these results suggest that URD in MM is feasible. The small number of patients with URD emphasizes the need to delineate indications and perform prospective protocols.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalEuropean Journal of Haematology
Volume88
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Allogeneic hematopoietic stem-cell transplantation
  • Multiple myeloma
  • Reduced-intensity conditioning
  • Unrelated donor

ASJC Scopus subject areas

  • Hematology

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