Comparable survival between HIV+ and HIV- non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation

José L. Díez-Martín, Pascual Balsalobre, Alessandro Re, Mariagrazia Michieli, José M. Ribera, Carmen Canals, Eulogio Conde, Anne Rosselet, Ian Gabriel, Rosario Varela, Bernardino Allione, Kate Cwynarski, Philippe Genet, Ildefonso Espigado, Pierre Biron, Norbert Schmitz, Anne E. Hunter, Augustin Ferrant, Gaelle Guillerm, Mark HentrichManuel Jurado, Pascual Fernández, David Serrano, Giuseppe Rossi, Anna Sureda

Research output: Contribution to journalArticlepeer-review

Abstract

Autologous stem cell transplantation (ASCT) has been successfully used in HIV-related lymphoma (HIV-Ly) patients on highly active antiretroviral therapy. We report the first comparative analysis between HIV-Ly and a matched cohort of HIV- lymphoma patients. This retrospective European Group for Blood and Marrow Transplantation study included 53 patients (66% non-Hodgkin and 34% Hodgkin lymphoma) within each cohort. Both groups were comparable except for the higher proportion of males, mixed-cellularity Hodgkin lymphoma and patients receiving granulocyte colony-stimulating factor before engraftment and a smaller proportion receiving total body irradiationbased conditioning within the HIV-Ly cohort. Incidence of relapse, overall survival, and progression-free survival were similar in both cohorts.Ahigher nonrelapse mortality within the first year after ASCT was observed in the HIV-Ly group (8% vs 2%), predominantly because of early bacterial infections, although this was not statistically significant and did not influence survival. Thus, within the highly active antiretroviral therapy era, HIV patients should be considered forASCT according to the same criteria adopted for HIV- lymphoma patients.

Original languageEnglish
Pages (from-to)6011-6014
Number of pages4
JournalBlood
Volume113
Issue number23
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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