Comparative analysis of iterative reconstruction algorithms with resolution recovery and time of flight modeling for 18F-FDG cardiac PET: A multi-center phantom study

Roberta Matheoud, Michela Lecchi, Domenico Lizio, Camilla Scabbio, Claudio Marcassa, Lucia Leva, Angelo Del Sole, Carlo Rodella, Luca Indovina, Christian Bracco, Marco Brambilla, Orazio Zoccarato

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The purpose of this study was to evaluate the image quality in cardiac 18F-FDG PET using the time of flight (TOF) and/or point spread function (PSF) modeling in the iterative reconstruction (IR). Methods: Three scanners and an anthropomorphic cardiac phantom with an insert simulating a transmural defect (TD) were used. Two sets of scans (with/without TD) were acquired, and four reconstruction schemes were considered: (1) IR; (2) IR + PSF, (3) IR + TOF, and (4) IR + TOF + PSF. LV wall thickness (FWHM), contrast between LV wall and inner chamber (CIC), and TD contrast in LV wall (CTD) were evaluated. Results: Tests of the reconstruction protocols showed a decrease in FWHM from IR (13 mm) to IR + PSF (11 mm); an increase in the CIC from IR (65%) to IR + PSF (71%) and from IR + TOF (72%) to IR + TOF + PSF (77%); and an increase in the CTD from IR + PSF (72%) to IR + TOF (75%) and to IR + TOF + PSF (77%). Tests of the scanner/software combinations showed a decrease in FWHM from Gemini_TF (13 mm) to Biograph_mCT (12 mm) and to Discovery_690 (11 mm); an increase in the CIC from Gemini_TF (65%) to Biograph_mCT (73%) and to Discovery_690 (75%); and an increase in the CTD from Gemini_TF/Biograph_mCT (72%) to Discovery_690 (77%). Conclusion: The introduction of TOF and PSF increases image quality in cardiac 18F-FDG PET. The scanner/software combinations exhibit different performances, which should be taken into consideration when making cross comparisons.

Original languageEnglish
Pages (from-to)1036-1045
Number of pages9
JournalJournal of Nuclear Cardiology
DOIs
Publication statusPublished - 2017

Keywords

  • cardiac
  • PET
  • point spread function
  • reconstruction algorithms
  • time of flight

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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