Comparative analysis of iterative reconstruction algorithms with resolution recovery for cardiac SPECT studies. A multi-center phantom study

Orazio Zoccarato, Camilla Scabbio, Elena De Ponti, Roberta Matheoud, Lucia Leva, Sabrina Morzenti, Marco Menzaghi, Riccardo Campini, Claudio Marcassa, Angelo Del Sole, Silvana Garancini, Cinzia Crivellaro, Marco Brambilla, Michela Lecchi

Research output: Contribution to journalArticlepeer-review


Background: This investigation used image data generated by a physical phantom over a wide range of count statistics to evaluate the effectiveness of several of the newer commercially available SPECT reconstruction iterative algorithms (IRR) in improving perfusion defect contrast and spatial resolution, while controlling image noise. Methods: A cardiac phantom was imaged using four different gamma cameras over a wide range of counts statistics (from 6 to 0.8 Mcounts). Images were reconstructed with FBP, OSEM, and the IRR available on site. IRR were applied without corrections (IRR NC), with attenuation correction (IRR AC), scatter correction (IRR SC), and attenuation + scatter corrections (IRR SCAC). Four image performance indices related to spatial resolution, contrast, and image noise were analyzed. Results: IRR NC always determined significant improvements in all indices in comparison to FBP or OSEM. Improvements were emphasized with IRR SC and IRR SCAC. Count reduction from 6 to 1.5 Mcounts did not impair the performances of any of the considered indices. Conclusions: This is the first study comparing the relative performance of different, commercially available, IRR software, over a wide range of count statistics; the additional effect of scatter and attenuation corrections, alone or in combination, was also evaluated. Our results confirm that IRR algorithms produce substantial benefits with respect to conventional FBP or OSEM reconstruction methods, as assessed through different figures of merit, in particular when SC and/or SCAC are also included.

Original languageEnglish
Pages (from-to)135-148
Number of pages14
JournalJournal of Nuclear Cardiology
Issue number1
Publication statusPublished - 2014


  • Iterative reconstruction
  • myocardial perfusion imaging
  • reconstruction algorithms
  • resolution recovery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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