Comparative analysis of iterative reconstruction algorithms with resolution recovery and time of flight modeling for (18)F-FDG cardiac PET: A multi-center phantom study.

Roberta Matheoud, Michela Lecchi, Domenico Lizio, Camilla Scabbio, Claudio Marcassa, Lucia Leva, Angelo Del Sole, Carlo Rodella, Luca Indovina, Christian Bracco, Marco Brambilla, Orazio Zoccarato

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Abstract

BACKGROUND: The purpose of this study was to evaluate the image quality in cardiac (18)F-FDG PET using the time of flight (TOF) and/or point spread function (PSF) modeling in the iterative reconstruction (IR). METHODS: Three scanners and an anthropomorphic cardiac phantom with an insert simulating a transmural defect (TD) were used. Two sets of scans (with/without TD) were acquired, and four reconstruction schemes were considered: (1) IR; (2) IR + PSF, (3) IR + TOF, and (4) IR + TOF + PSF. LV wall thickness (FWHM), contrast between LV wall and inner chamber (C IC), and TD contrast in LV wall (C TD) were evaluated. RESULTS: Tests of the reconstruction protocols showed a decrease in FWHM from IR (13 mm) to IR + PSF (11 mm); an increase in the C IC from IR (65%) to IR + PSF (71%) and from IR + TOF (72%) to IR + TOF + PSF (77%); and an increase in the C TD from IR + PSF (72%) to IR + TOF (75%) and to IR + TOF + PSF (77%). Tests of the scanner/software combinations showed a decrease in FWHM from Gemini_TF (13 mm) to Biograph_mCT (12 mm) and to Discovery_690 (11 mm); an increase in the C IC from Gemini_TF (65%) to Biograph_mCT (73%) and to Discovery_690 (75%); and an increase in the C TD from Gemini_TF/Biograph_mCT (72%) to Discovery_690 (77%). CONCLUSION: The introduction of TOF and PSF increases image quality in cardiac (18)F-FDG PET. The scanner/software combinations exhibit different performances, which should be taken into consideration when making cross comparisons.
Original languageEnglish
Pages (from-to)1036-1045
Number of pages10
JournalJournal of Nuclear Cardiology
Volume24
Publication statusPublished - Jun 1 2017

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  • PET, cardiac, point spread function, reconstruction algorithms, time of flight

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Comparative analysis of iterative reconstruction algorithms with resolution recovery and time of flight modeling for (18)F-FDG cardiac PET: A multi-center phantom study. / Matheoud, Roberta; Lecchi, Michela; Lizio, Domenico; Scabbio, Camilla; Marcassa, Claudio; Leva, Lucia; Del Sole, Angelo; Rodella, Carlo; Indovina, Luca; Bracco, Christian; Brambilla, Marco; Zoccarato, Orazio.

In: Journal of Nuclear Cardiology, Vol. 24, 01.06.2017, p. 1036-1045.

Research output: Contribution to journalArticle

Matheoud, Roberta ; Lecchi, Michela ; Lizio, Domenico ; Scabbio, Camilla ; Marcassa, Claudio ; Leva, Lucia ; Del Sole, Angelo ; Rodella, Carlo ; Indovina, Luca ; Bracco, Christian ; Brambilla, Marco ; Zoccarato, Orazio. / Comparative analysis of iterative reconstruction algorithms with resolution recovery and time of flight modeling for (18)F-FDG cardiac PET: A multi-center phantom study. In: Journal of Nuclear Cardiology. 2017 ; Vol. 24. pp. 1036-1045.
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title = "Comparative analysis of iterative reconstruction algorithms with resolution recovery and time of flight modeling for (18)F-FDG cardiac PET: A multi-center phantom study.",
abstract = "BACKGROUND: The purpose of this study was to evaluate the image quality in cardiac (18)F-FDG PET using the time of flight (TOF) and/or point spread function (PSF) modeling in the iterative reconstruction (IR). METHODS: Three scanners and an anthropomorphic cardiac phantom with an insert simulating a transmural defect (TD) were used. Two sets of scans (with/without TD) were acquired, and four reconstruction schemes were considered: (1) IR; (2) IR + PSF, (3) IR + TOF, and (4) IR + TOF + PSF. LV wall thickness (FWHM), contrast between LV wall and inner chamber (C IC), and TD contrast in LV wall (C TD) were evaluated. RESULTS: Tests of the reconstruction protocols showed a decrease in FWHM from IR (13 mm) to IR + PSF (11 mm); an increase in the C IC from IR (65{\%}) to IR + PSF (71{\%}) and from IR + TOF (72{\%}) to IR + TOF + PSF (77{\%}); and an increase in the C TD from IR + PSF (72{\%}) to IR + TOF (75{\%}) and to IR + TOF + PSF (77{\%}). Tests of the scanner/software combinations showed a decrease in FWHM from Gemini_TF (13 mm) to Biograph_mCT (12 mm) and to Discovery_690 (11 mm); an increase in the C IC from Gemini_TF (65{\%}) to Biograph_mCT (73{\%}) and to Discovery_690 (75{\%}); and an increase in the C TD from Gemini_TF/Biograph_mCT (72{\%}) to Discovery_690 (77{\%}). CONCLUSION: The introduction of TOF and PSF increases image quality in cardiac (18)F-FDG PET. The scanner/software combinations exhibit different performances, which should be taken into consideration when making cross comparisons.",
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T1 - Comparative analysis of iterative reconstruction algorithms with resolution recovery and time of flight modeling for (18)F-FDG cardiac PET: A multi-center phantom study.

AU - Matheoud, Roberta

AU - Lecchi, Michela

AU - Lizio, Domenico

AU - Scabbio, Camilla

AU - Marcassa, Claudio

AU - Leva, Lucia

AU - Del Sole, Angelo

AU - Rodella, Carlo

AU - Indovina, Luca

AU - Bracco, Christian

AU - Brambilla, Marco

AU - Zoccarato, Orazio

PY - 2017/6/1

Y1 - 2017/6/1

N2 - BACKGROUND: The purpose of this study was to evaluate the image quality in cardiac (18)F-FDG PET using the time of flight (TOF) and/or point spread function (PSF) modeling in the iterative reconstruction (IR). METHODS: Three scanners and an anthropomorphic cardiac phantom with an insert simulating a transmural defect (TD) were used. Two sets of scans (with/without TD) were acquired, and four reconstruction schemes were considered: (1) IR; (2) IR + PSF, (3) IR + TOF, and (4) IR + TOF + PSF. LV wall thickness (FWHM), contrast between LV wall and inner chamber (C IC), and TD contrast in LV wall (C TD) were evaluated. RESULTS: Tests of the reconstruction protocols showed a decrease in FWHM from IR (13 mm) to IR + PSF (11 mm); an increase in the C IC from IR (65%) to IR + PSF (71%) and from IR + TOF (72%) to IR + TOF + PSF (77%); and an increase in the C TD from IR + PSF (72%) to IR + TOF (75%) and to IR + TOF + PSF (77%). Tests of the scanner/software combinations showed a decrease in FWHM from Gemini_TF (13 mm) to Biograph_mCT (12 mm) and to Discovery_690 (11 mm); an increase in the C IC from Gemini_TF (65%) to Biograph_mCT (73%) and to Discovery_690 (75%); and an increase in the C TD from Gemini_TF/Biograph_mCT (72%) to Discovery_690 (77%). CONCLUSION: The introduction of TOF and PSF increases image quality in cardiac (18)F-FDG PET. The scanner/software combinations exhibit different performances, which should be taken into consideration when making cross comparisons.

AB - BACKGROUND: The purpose of this study was to evaluate the image quality in cardiac (18)F-FDG PET using the time of flight (TOF) and/or point spread function (PSF) modeling in the iterative reconstruction (IR). METHODS: Three scanners and an anthropomorphic cardiac phantom with an insert simulating a transmural defect (TD) were used. Two sets of scans (with/without TD) were acquired, and four reconstruction schemes were considered: (1) IR; (2) IR + PSF, (3) IR + TOF, and (4) IR + TOF + PSF. LV wall thickness (FWHM), contrast between LV wall and inner chamber (C IC), and TD contrast in LV wall (C TD) were evaluated. RESULTS: Tests of the reconstruction protocols showed a decrease in FWHM from IR (13 mm) to IR + PSF (11 mm); an increase in the C IC from IR (65%) to IR + PSF (71%) and from IR + TOF (72%) to IR + TOF + PSF (77%); and an increase in the C TD from IR + PSF (72%) to IR + TOF (75%) and to IR + TOF + PSF (77%). Tests of the scanner/software combinations showed a decrease in FWHM from Gemini_TF (13 mm) to Biograph_mCT (12 mm) and to Discovery_690 (11 mm); an increase in the C IC from Gemini_TF (65%) to Biograph_mCT (73%) and to Discovery_690 (75%); and an increase in the C TD from Gemini_TF/Biograph_mCT (72%) to Discovery_690 (77%). CONCLUSION: The introduction of TOF and PSF increases image quality in cardiac (18)F-FDG PET. The scanner/software combinations exhibit different performances, which should be taken into consideration when making cross comparisons.

KW - PET, cardiac, point spread function, reconstruction algorithms, time of flight

M3 - Article

VL - 24

SP - 1036

EP - 1045

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

ER -