Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain

Matías Hidalgo-Sánchez, Sandrine Millet, Antonio Simeone, Rosa Magda Alvarado-Mallart

Research output: Contribution to journalArticle

Abstract

The patterns of the Gbx2, Pax2, Wnt1, and Fgf8 gene expression were analyzed in the chick with respect to the caudal limit of the Otx2 anterior domain, taken as a landmark of the midbrain/hindbrain (MH) boundary. The Gbx2 anterior boundary is always concomitant with the Otx2 posterior boundary. The ring of Wnt1 expression is included within the Otx2 domain and Fgf8 transcripts included within the Gbx2 neuroepithelium. Pax2 expression is centred on the MH boundary with a double decreasing gradient. We propose a new nomenclature to differentiate the vesicles and constrictions observed in the avian MH domain at stage HH10 and HH20, based on the localization of the Gbx2/Otx2 common boundary.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalMechanisms of Development
Volume81
Issue number1-2
DOIs
Publication statusPublished - Mar 1 1999

    Fingerprint

Keywords

  • Cerebellum
  • Development
  • Mes/met constriction
  • Mesencephalon
  • Neural tube segmentation
  • Otx2 expression

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this