Comparative analysis of the human dystrophin and utrophin gene structures

Uberto Pozzoli; Manuela Sironi; Rachele Cagliani; Giacomo P. Comi; Alessandra Bardoni; Nereo Bresolin

Comparative analysis of the human dystrophin and utrophin gene structures

Uberto Pozzoli, Manuela Sironi, Rachele Cagliani, Giacomo P. Comi, Alessandra Bardoni, Nereo Bresolin

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Abstract

We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.

Original language	English
Pages (from-to)	793-798
Number of pages	6
Journal	Genetics
Volume	160
Issue number	2
Publication status	Published - 2002

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Genetics
Genetics(clinical)

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Pozzoli, U., Sironi, M., Cagliani, R., Comi, G. P., Bardoni, A., & Bresolin, N. (2002). Comparative analysis of the human dystrophin and utrophin gene structures. Genetics, 160(2), 793-798.

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AU - Bardoni, Alessandra

AU - Bresolin, Nereo

PY - 2002

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AB - We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.

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Comparative analysis of the human dystrophin and utrophin gene structures

Abstract

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