Comparative analysis of the human dystrophin and utrophin gene structures

Uberto Pozzoli; Manuela Sironi; Rachele Cagliani; Giacomo P. Comi; Alessandra Bardoni; Nereo Bresolin

Comparative analysis of the human dystrophin and utrophin gene structures

Uberto Pozzoli, Manuela Sironi, Rachele Cagliani, Giacomo P. Comi, Alessandra Bardoni, Nereo Bresolin

Research output: Contribution to journal › Article › peer-review

Abstract

We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.

Original language	English
Pages (from-to)	793-798
Number of pages	6
Journal	Genetics
Volume	160
Issue number	2
Publication status	Published - 2002

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

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abstract = "We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.",

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AU - Sironi, Manuela

AU - Cagliani, Rachele

AU - Comi, Giacomo P.

AU - Bardoni, Alessandra

AU - Bresolin, Nereo

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AB - We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.

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Comparative analysis of the human dystrophin and utrophin gene structures

Abstract

ASJC Scopus subject areas

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