Comparative analysis of the human dystrophin and utrophin gene structures

Uberto Pozzoli; Manuela Sironi; Rachele Cagliani; Giacomo P. Comi; Alessandra Bardoni; Nereo Bresolin

Comparative analysis of the human dystrophin and utrophin gene structures

Uberto Pozzoli, Manuela Sironi, Rachele Cagliani, Giacomo P. Comi, Alessandra Bardoni, Nereo Bresolin

Research output: Contribution to journal › Article

Abstract

We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.

Original language	English
Pages (from-to)	793-798
Number of pages	6
Journal	Genetics
Volume	160
Issue number	2
Publication status	Published - 2002

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

Fingerprint Dive into the research topics of 'Comparative analysis of the human dystrophin and utrophin gene structures'. Together they form a unique fingerprint.

Cite this

Pozzoli, U., Sironi, M., Cagliani, R., Comi, G. P., Bardoni, A., & Bresolin, N. (2002). Comparative analysis of the human dystrophin and utrophin gene structures. Genetics, 160(2), 793-798.

@article{c6c37651cfab4a08b00f441af7f2cfe3,

title = "Comparative analysis of the human dystrophin and utrophin gene structures",

abstract = "We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.",

author = "Uberto Pozzoli and Manuela Sironi and Rachele Cagliani and Comi, {Giacomo P.} and Alessandra Bardoni and Nereo Bresolin",

year = "2002",

language = "English",

volume = "160",

pages = "793--798",

journal = "Genetics",

issn = "0016-6731",

publisher = "Genetics Society of America",

number = "2",

}

TY - JOUR

T1 - Comparative analysis of the human dystrophin and utrophin gene structures

AU - Pozzoli, Uberto

AU - Sironi, Manuela

AU - Cagliani, Rachele

AU - Comi, Giacomo P.

AU - Bardoni, Alessandra

AU - Bresolin, Nereo

PY - 2002

Y1 - 2002

N2 - We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.

AB - We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.

UR - http://www.scopus.com/inward/record.url?scp=0036189829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036189829&partnerID=8YFLogxK

M3 - Article

C2 - 11861579

AN - SCOPUS:0036189829

VL - 160

SP - 793

EP - 798

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 2

ER -