Abstract
Objective: Major depressive disorder (MDD) is a psychiatric condition with high prevalence and poor treatment outcomes. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method with pilot trials showing promising results; however, it is still unclear the profile of patients in which tDCS is better indicated. Therefore, the aim of this study is to compare tDCS efficacy according to depression severity. Method: Thirty-two hospitalized patients (24 women) aged 30-70; with MDD according to DSM-IV.TR criteria were included. Drug treatment was not changed during the study. Mood was evaluated using the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI). Patients were divided into two groups according to MDD severity, as measured by BDI (mild/moderate vs. severe). Anodal tDCS was bilaterally delivered to the Dorsolateral Prefrontal Cortex (DLPFC), using a stimulating current of 2 mA intensity for 20 minutes, twice a day, for 5 days consecutively. Depression was measured at baseline and after 5 (Tl), 12 (T2) and 35 (T3) days from the start of tDCS treatment. Results: Treatment was well tolerated without side effects. tDCS was effective in ameliorating depressive symptoms, with a significant mean BDI reduction of 11.1 (p1203 = 11.0, p1193= 8.1, p
| Original language | English |
|---|---|
| Pages (from-to) | 246-251 |
| Number of pages | 6 |
| Journal | Clinical Neuropsychiatry |
| Volume | 6 |
| Issue number | 6 |
| Publication status | Published - Dec 2009 |
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Keywords
- Major depressive disorder
- Mood
- Non-invasive brain stimulation
- Transcranial direct current stimulation
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Comparative benefits of transcranial direct current stimulation (TDCS) treatment in patients with mild/moderate vs. severe depression. / Ferrucci, Roberta; Bortolomasi, Marco; Brunoni, Andre; Vergari, Maurizio; Tadini, Laura; Giacopuzzi, Mario; Priori, Alberto.
In: Clinical Neuropsychiatry, Vol. 6, No. 6, 12.2009, p. 246-251.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative benefits of transcranial direct current stimulation (TDCS) treatment in patients with mild/moderate vs. severe depression
AU - Ferrucci, Roberta
AU - Bortolomasi, Marco
AU - Brunoni, Andre
AU - Vergari, Maurizio
AU - Tadini, Laura
AU - Giacopuzzi, Mario
AU - Priori, Alberto
PY - 2009/12
Y1 - 2009/12
N2 - Objective: Major depressive disorder (MDD) is a psychiatric condition with high prevalence and poor treatment outcomes. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method with pilot trials showing promising results; however, it is still unclear the profile of patients in which tDCS is better indicated. Therefore, the aim of this study is to compare tDCS efficacy according to depression severity. Method: Thirty-two hospitalized patients (24 women) aged 30-70; with MDD according to DSM-IV.TR criteria were included. Drug treatment was not changed during the study. Mood was evaluated using the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI). Patients were divided into two groups according to MDD severity, as measured by BDI (mild/moderate vs. severe). Anodal tDCS was bilaterally delivered to the Dorsolateral Prefrontal Cortex (DLPFC), using a stimulating current of 2 mA intensity for 20 minutes, twice a day, for 5 days consecutively. Depression was measured at baseline and after 5 (Tl), 12 (T2) and 35 (T3) days from the start of tDCS treatment. Results: Treatment was well tolerated without side effects. tDCS was effective in ameliorating depressive symptoms, with a significant mean BDI reduction of 11.1 (p1203 = 11.0, p1193= 8.1, p
AB - Objective: Major depressive disorder (MDD) is a psychiatric condition with high prevalence and poor treatment outcomes. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method with pilot trials showing promising results; however, it is still unclear the profile of patients in which tDCS is better indicated. Therefore, the aim of this study is to compare tDCS efficacy according to depression severity. Method: Thirty-two hospitalized patients (24 women) aged 30-70; with MDD according to DSM-IV.TR criteria were included. Drug treatment was not changed during the study. Mood was evaluated using the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI). Patients were divided into two groups according to MDD severity, as measured by BDI (mild/moderate vs. severe). Anodal tDCS was bilaterally delivered to the Dorsolateral Prefrontal Cortex (DLPFC), using a stimulating current of 2 mA intensity for 20 minutes, twice a day, for 5 days consecutively. Depression was measured at baseline and after 5 (Tl), 12 (T2) and 35 (T3) days from the start of tDCS treatment. Results: Treatment was well tolerated without side effects. tDCS was effective in ameliorating depressive symptoms, with a significant mean BDI reduction of 11.1 (p1203 = 11.0, p1193= 8.1, p
KW - Major depressive disorder
KW - Mood
KW - Non-invasive brain stimulation
KW - Transcranial direct current stimulation
UR - http://www.scopus.com/inward/record.url?scp=74749085073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74749085073&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:74749085073
VL - 6
SP - 246
EP - 251
JO - Clinical Neuropsychiatry
JF - Clinical Neuropsychiatry
SN - 1724-4935
IS - 6
ER -