Comparative benefits of transcranial direct current stimulation (TDCS) treatment in patients with mild/moderate vs. severe depression

Roberta Ferrucci, Marco Bortolomasi, Andre Brunoni, Maurizio Vergari, Laura Tadini, Mario Giacopuzzi, Alberto Priori

Research output: Contribution to journalArticle

Abstract

Objective: Major depressive disorder (MDD) is a psychiatric condition with high prevalence and poor treatment outcomes. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method with pilot trials showing promising results; however, it is still unclear the profile of patients in which tDCS is better indicated. Therefore, the aim of this study is to compare tDCS efficacy according to depression severity. Method: Thirty-two hospitalized patients (24 women) aged 30-70; with MDD according to DSM-IV.TR criteria were included. Drug treatment was not changed during the study. Mood was evaluated using the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI). Patients were divided into two groups according to MDD severity, as measured by BDI (mild/moderate vs. severe). Anodal tDCS was bilaterally delivered to the Dorsolateral Prefrontal Cortex (DLPFC), using a stimulating current of 2 mA intensity for 20 minutes, twice a day, for 5 days consecutively. Depression was measured at baseline and after 5 (Tl), 12 (T2) and 35 (T3) days from the start of tDCS treatment. Results: Treatment was well tolerated without side effects. tDCS was effective in ameliorating depressive symptoms, with a significant mean BDI reduction of 11.1 (p1203 = 11.0, p1193= 8.1, p

Original languageEnglish
Pages (from-to)246-251
Number of pages6
JournalClinical Neuropsychiatry
Volume6
Issue number6
Publication statusPublished - Dec 2009

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Depression
Major Depressive Disorder
Equipment and Supplies
Therapeutics
Transcranial Direct Current Stimulation
Prefrontal Cortex
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Brain
Pharmaceutical Preparations

Keywords

  • Major depressive disorder
  • Mood
  • Non-invasive brain stimulation
  • Transcranial direct current stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Comparative benefits of transcranial direct current stimulation (TDCS) treatment in patients with mild/moderate vs. severe depression. / Ferrucci, Roberta; Bortolomasi, Marco; Brunoni, Andre; Vergari, Maurizio; Tadini, Laura; Giacopuzzi, Mario; Priori, Alberto.

In: Clinical Neuropsychiatry, Vol. 6, No. 6, 12.2009, p. 246-251.

Research output: Contribution to journalArticle

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