Comparative effect of thiamphenicol glycinate, thiamphenicol glycinate N-acetylcysteinate, amoxicillin plus clavulanic acid, ceftriaxone and clarithromycin on pulmonary clearance of Haemophilus influenzae in an animal model

Lorenzo Drago, Maria Cristina Fassina, Barbara Mombelli, Elena De Vecchi, Alessandra Lombardi, Maria Rita Gismondo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Thiamphenicol glycinate (TG) and its derivative thiamphenicol glycinate N-acetylcysteinate (TGA) could be a valid therapeutic option in the treatment of respiratory tract infections. Methods: Time-kill curves of TG and TGA and pulmonary clearance in Haemophilus influenzae infected guinea pigs were compared with those of clarithromycin, ceftriaxone and amoxicillin plus clavulanic acid. Results: The bacterial activities of the tested antibiotics were comparable. When compared to the control group, lung bacterial counts were significantly lower for the TGA group at 3 h vs. controls, while for the other treatments, significant decreases were recorded after 6 h. All drugs showed a log count of

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalChemotherapy
Volume46
Issue number4
Publication statusPublished - 2000

Keywords

  • Amoxicillin plus clavulanic acid
  • Ceftriaxone
  • Clarithromycin
  • Guinea pigs
  • Haemophilus influenzae
  • Thiamphenicol

ASJC Scopus subject areas

  • Pharmacology (medical)

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