Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study

Cesare Cuspidi; M. Lorenza Muiesan; Laura Valagussa; Massimo Salvetti; Carlo Di Biagio; Enrico Agabiti-Rosei; Bruno Magnani; Alberto Zanchetti; E. Bartoli; F. Bux; V. Calcaterra; S. Pancaldi; A. Capucci; G. Devenuto; R. De Cesaris; G. Di Biase; G. Di Pasquale; M. Guglielmi; A. Mezzetti; G. Pinelli; G. Pinna; F. Portaluppi; I. Russo; G. Saba; T. Scarpelli; E. Uslenghi; M. Keck; T. Beyer; K. H. Tepel; H. Schobel; U. Stolzel; B. Metscher; S. Gehlhar; H. Loos; K. Busch; G. Clasen; T. R. Muller; K. Colberg; C. Ulbrich; D. Langguth; V. Mitrovich; V. Regitz-Zagrosek; M. Rittich; J. L. Weber

doi:10.1097/00004872-200211000-00030

Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study

Cesare Cuspidi, M. Lorenza Muiesan, Laura Valagussa, Massimo Salvetti, Carlo Di Biagio, Enrico Agabiti-Rosei, Bruno Magnani, Alberto Zanchetti, E. Bartoli, F. Bux, V. Calcaterra, S. Pancaldi, A. Capucci, G. Devenuto, R. De Cesaris, G. Di Biase, G. Di Pasquale, M. Guglielmi, A. Mezzetti, G. PinelliG. Pinna, F. Portaluppi, I. Russo, G. Saba, T. Scarpelli, E. Uslenghi, M. Keck, T. Beyer, K. H. Tepel, H. Schobel, U. Stolzel, B. Metscher, S. Gehlhar, H. Loos, K. Busch, G. Clasen, T. R. Muller, K. Colberg, C. Ulbrich, D. Langguth, V. Mitrovich, V. Regitz-Zagrosek, M. Rittich, J. L. Weber

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Background: A limited number of studies have evaluated the effect of angiotensin II receptor antagonists (AIIAs) on left ventricular hypertrophy (LVH) in comparison with other antihypertensive drugs, and no large study has compared AIIAs with angiotensin-converting enzyme inhibitors (ACEIs). Methods and results: The CATCH (Candesartan Assessment in the Treatment of Cardiac Hypertrophy) study was a multicenter prospective randomized double-blind trial comparing the effects of candesartan cilexetil (8-16 mg once daily) and enalapril (10-20 mg once daily) with possible addition of hydrochlorothiazide (12.5-25 mg once daily) on echocardiographic left ventricular mass index (LVMI), in 239 hypertensives with LVH (LVMI>120 g/m² in men and >100 g/m² in women). Two-dimensionally guided M-mode echocardiograms were carried out at screening (recruiting scan), randomization (baseline scan) and after 24 and 48 weeks of treatment. Baseline and treatment echocardiograms were read at two central labs without knowledge of the scan time sequence. In intention-to-treat (ITT) analyses (196 patients), systolic and diastolic blood pressures (SBP, DBP) were significantly and equally reduced by the two treatments. Candesartan and enalapril reduced LVMI to the same extent, i.e. by 15.0 and 13.1 g/m² (-10.9 and -8.4%; P

Original language	English
Pages (from-to)	2293-2300
Number of pages	8
Journal	Journal of Hypertension
Volume	20
Issue number	11
DOIs	https://doi.org/10.1097/00004872-200211000-00030
Publication status	Published - Nov 2002

Keywords

Drugs
Echocardiography
Hypertension
Hypertrophy

ASJC Scopus subject areas

Internal Medicine
Endocrinology

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10.1097/00004872-200211000-00030

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Cuspidi, C., Muiesan, M. L., Valagussa, L., Salvetti, M., Di Biagio, C., Agabiti-Rosei, E., Magnani, B., Zanchetti, A., Bartoli, E., Bux, F., Calcaterra, V., Pancaldi, S., Capucci, A., Devenuto, G., De Cesaris, R., Di Biase, G., Di Pasquale, G., Guglielmi, M., Mezzetti, A., ... Weber, J. L. (2002). Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study. Journal of Hypertension, 20(11), 2293-2300. https://doi.org/10.1097/00004872-200211000-00030

Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension : The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study. / Cuspidi, Cesare; Muiesan, M. Lorenza; Valagussa, Laura; Salvetti, Massimo; Di Biagio, Carlo; Agabiti-Rosei, Enrico; Magnani, Bruno; Zanchetti, Alberto; Bartoli, E.; Bux, F.; Calcaterra, V.; Pancaldi, S.; Capucci, A.; Devenuto, G.; De Cesaris, R.; Di Biase, G.; Di Pasquale, G.; Guglielmi, M.; Mezzetti, A.; Pinelli, G.; Pinna, G.; Portaluppi, F.; Russo, I.; Saba, G.; Scarpelli, T.; Uslenghi, E.; Keck, M.; Beyer, T.; Tepel, K. H.; Schobel, H.; Stolzel, U.; Metscher, B.; Gehlhar, S.; Loos, H.; Busch, K.; Clasen, G.; Muller, T. R.; Colberg, K.; Ulbrich, C.; Langguth, D.; Mitrovich, V.; Regitz-Zagrosek, V.; Rittich, M.; Weber, J. L.

In: Journal of Hypertension, Vol. 20, No. 11, 11.2002, p. 2293-2300.

Research output: Contribution to journal › Article › peer-review

Cuspidi, C, Muiesan, ML, Valagussa, L, Salvetti, M, Di Biagio, C, Agabiti-Rosei, E, Magnani, B, Zanchetti, A, Bartoli, E, Bux, F, Calcaterra, V, Pancaldi, S, Capucci, A, Devenuto, G, De Cesaris, R, Di Biase, G, Di Pasquale, G, Guglielmi, M, Mezzetti, A, Pinelli, G, Pinna, G, Portaluppi, F, Russo, I, Saba, G, Scarpelli, T, Uslenghi, E, Keck, M, Beyer, T, Tepel, KH, Schobel, H, Stolzel, U, Metscher, B, Gehlhar, S, Loos, H, Busch, K, Clasen, G, Muller, TR, Colberg, K, Ulbrich, C, Langguth, D, Mitrovich, V, Regitz-Zagrosek, V, Rittich, M & Weber, JL 2002, 'Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study', Journal of Hypertension, vol. 20, no. 11, pp. 2293-2300. https://doi.org/10.1097/00004872-200211000-00030

Cuspidi C, Muiesan ML, Valagussa L, Salvetti M, Di Biagio C, Agabiti-Rosei E et al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study. Journal of Hypertension. 2002 Nov;20(11):2293-2300. https://doi.org/10.1097/00004872-200211000-00030

Cuspidi, Cesare ; Muiesan, M. Lorenza ; Valagussa, Laura ; Salvetti, Massimo ; Di Biagio, Carlo ; Agabiti-Rosei, Enrico ; Magnani, Bruno ; Zanchetti, Alberto ; Bartoli, E. ; Bux, F. ; Calcaterra, V. ; Pancaldi, S. ; Capucci, A. ; Devenuto, G. ; De Cesaris, R. ; Di Biase, G. ; Di Pasquale, G. ; Guglielmi, M. ; Mezzetti, A. ; Pinelli, G. ; Pinna, G. ; Portaluppi, F. ; Russo, I. ; Saba, G. ; Scarpelli, T. ; Uslenghi, E. ; Keck, M. ; Beyer, T. ; Tepel, K. H. ; Schobel, H. ; Stolzel, U. ; Metscher, B. ; Gehlhar, S. ; Loos, H. ; Busch, K. ; Clasen, G. ; Muller, T. R. ; Colberg, K. ; Ulbrich, C. ; Langguth, D. ; Mitrovich, V. ; Regitz-Zagrosek, V. ; Rittich, M. ; Weber, J. L. / Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension : The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study. In: Journal of Hypertension. 2002 ; Vol. 20, No. 11. pp. 2293-2300.

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title = "Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study",

abstract = "Background: A limited number of studies have evaluated the effect of angiotensin II receptor antagonists (AIIAs) on left ventricular hypertrophy (LVH) in comparison with other antihypertensive drugs, and no large study has compared AIIAs with angiotensin-converting enzyme inhibitors (ACEIs). Methods and results: The CATCH (Candesartan Assessment in the Treatment of Cardiac Hypertrophy) study was a multicenter prospective randomized double-blind trial comparing the effects of candesartan cilexetil (8-16 mg once daily) and enalapril (10-20 mg once daily) with possible addition of hydrochlorothiazide (12.5-25 mg once daily) on echocardiographic left ventricular mass index (LVMI), in 239 hypertensives with LVH (LVMI>120 g/m2 in men and >100 g/m2 in women). Two-dimensionally guided M-mode echocardiograms were carried out at screening (recruiting scan), randomization (baseline scan) and after 24 and 48 weeks of treatment. Baseline and treatment echocardiograms were read at two central labs without knowledge of the scan time sequence. In intention-to-treat (ITT) analyses (196 patients), systolic and diastolic blood pressures (SBP, DBP) were significantly and equally reduced by the two treatments. Candesartan and enalapril reduced LVMI to the same extent, i.e. by 15.0 and 13.1 g/m2 (-10.9 and -8.4%; P",

keywords = "Drugs, Echocardiography, Hypertension, Hypertrophy",

author = "Cesare Cuspidi and Muiesan, {M. Lorenza} and Laura Valagussa and Massimo Salvetti and {Di Biagio}, Carlo and Enrico Agabiti-Rosei and Bruno Magnani and Alberto Zanchetti and E. Bartoli and F. Bux and V. Calcaterra and S. Pancaldi and A. Capucci and G. Devenuto and {De Cesaris}, R. and {Di Biase}, G. and {Di Pasquale}, G. and M. Guglielmi and A. Mezzetti and G. Pinelli and G. Pinna and F. Portaluppi and I. Russo and G. Saba and T. Scarpelli and E. Uslenghi and M. Keck and T. Beyer and Tepel, {K. H.} and H. Schobel and U. Stolzel and B. Metscher and S. Gehlhar and H. Loos and K. Busch and G. Clasen and Muller, {T. R.} and K. Colberg and C. Ulbrich and D. Langguth and V. Mitrovich and V. Regitz-Zagrosek and M. Rittich and Weber, {J. L.}",

year = "2002",

month = nov,

doi = "10.1097/00004872-200211000-00030",

language = "English",

volume = "20",

pages = "2293--2300",

journal = "Journal of Hypertension",

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T1 - Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension

T2 - The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study

AU - Cuspidi, Cesare

AU - Muiesan, M. Lorenza

AU - Valagussa, Laura

AU - Salvetti, Massimo

AU - Di Biagio, Carlo

AU - Agabiti-Rosei, Enrico

AU - Magnani, Bruno

AU - Zanchetti, Alberto

AU - Bartoli, E.

AU - Bux, F.

AU - Calcaterra, V.

AU - Pancaldi, S.

AU - Capucci, A.

AU - Devenuto, G.

AU - De Cesaris, R.

AU - Di Biase, G.

AU - Di Pasquale, G.

AU - Guglielmi, M.

AU - Mezzetti, A.

AU - Pinelli, G.

AU - Pinna, G.

AU - Portaluppi, F.

AU - Russo, I.

AU - Saba, G.

AU - Scarpelli, T.

AU - Uslenghi, E.

AU - Keck, M.

AU - Beyer, T.

AU - Tepel, K. H.

AU - Schobel, H.

AU - Stolzel, U.

AU - Metscher, B.

AU - Gehlhar, S.

AU - Loos, H.

AU - Busch, K.

AU - Clasen, G.

AU - Muller, T. R.

AU - Colberg, K.

AU - Ulbrich, C.

AU - Langguth, D.

AU - Mitrovich, V.

AU - Regitz-Zagrosek, V.

AU - Rittich, M.

AU - Weber, J. L.

PY - 2002/11

Y1 - 2002/11

N2 - Background: A limited number of studies have evaluated the effect of angiotensin II receptor antagonists (AIIAs) on left ventricular hypertrophy (LVH) in comparison with other antihypertensive drugs, and no large study has compared AIIAs with angiotensin-converting enzyme inhibitors (ACEIs). Methods and results: The CATCH (Candesartan Assessment in the Treatment of Cardiac Hypertrophy) study was a multicenter prospective randomized double-blind trial comparing the effects of candesartan cilexetil (8-16 mg once daily) and enalapril (10-20 mg once daily) with possible addition of hydrochlorothiazide (12.5-25 mg once daily) on echocardiographic left ventricular mass index (LVMI), in 239 hypertensives with LVH (LVMI>120 g/m2 in men and >100 g/m2 in women). Two-dimensionally guided M-mode echocardiograms were carried out at screening (recruiting scan), randomization (baseline scan) and after 24 and 48 weeks of treatment. Baseline and treatment echocardiograms were read at two central labs without knowledge of the scan time sequence. In intention-to-treat (ITT) analyses (196 patients), systolic and diastolic blood pressures (SBP, DBP) were significantly and equally reduced by the two treatments. Candesartan and enalapril reduced LVMI to the same extent, i.e. by 15.0 and 13.1 g/m2 (-10.9 and -8.4%; P

AB - Background: A limited number of studies have evaluated the effect of angiotensin II receptor antagonists (AIIAs) on left ventricular hypertrophy (LVH) in comparison with other antihypertensive drugs, and no large study has compared AIIAs with angiotensin-converting enzyme inhibitors (ACEIs). Methods and results: The CATCH (Candesartan Assessment in the Treatment of Cardiac Hypertrophy) study was a multicenter prospective randomized double-blind trial comparing the effects of candesartan cilexetil (8-16 mg once daily) and enalapril (10-20 mg once daily) with possible addition of hydrochlorothiazide (12.5-25 mg once daily) on echocardiographic left ventricular mass index (LVMI), in 239 hypertensives with LVH (LVMI>120 g/m2 in men and >100 g/m2 in women). Two-dimensionally guided M-mode echocardiograms were carried out at screening (recruiting scan), randomization (baseline scan) and after 24 and 48 weeks of treatment. Baseline and treatment echocardiograms were read at two central labs without knowledge of the scan time sequence. In intention-to-treat (ITT) analyses (196 patients), systolic and diastolic blood pressures (SBP, DBP) were significantly and equally reduced by the two treatments. Candesartan and enalapril reduced LVMI to the same extent, i.e. by 15.0 and 13.1 g/m2 (-10.9 and -8.4%; P

KW - Drugs

KW - Echocardiography

KW - Hypertension

KW - Hypertrophy

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Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: The candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study

Abstract

Keywords

ASJC Scopus subject areas

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