Comparative effects of chronic haloperidol and sulpiride treatment on nigral and striatal GABA content

F. Nicoletti, F. Patti, D. F. Condorelli, L. Rampello, G. Giammona, R. M. Di Giorgio, P. L. Canonico, U. Scapagnini

Research output: Contribution to journalArticle

Abstract

Nigral and striatal GABA contents were assayed in male rats treated chronically with haloperidol or sulpiride, two dopamine-receptor blocking agents that have different neuropharmacological spectra in regard to their biochemical, behavioural, and clinical properties. No great difference was observed between the chronic effects of haloperidol and sulpiride on nigral and striatal GABA content. However, low doses (30μg/kg, intraperitoneally) of the dopamine-receptor agonist apomorphine, injected 12 h after the discontinuation of chronic haloperidol or chronic sulpiride treatment, induced opposite changes in nigral GABA levels suggesting the existence of a different 'status' of the dopamine receptors during the 12 h-period following the withdrawal of haloperidol or sulpiride.

Original languageEnglish
Pages (from-to)1048-1051
Number of pages4
JournalJournal of Neurochemistry
Volume37
Issue number4
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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    Nicoletti, F., Patti, F., Condorelli, D. F., Rampello, L., Giammona, G., Di Giorgio, R. M., Canonico, P. L., & Scapagnini, U. (1981). Comparative effects of chronic haloperidol and sulpiride treatment on nigral and striatal GABA content. Journal of Neurochemistry, 37(4), 1048-1051.