Comparative effects of estrogens and prolactin on nigral and striatal GAD activity

Fernando Nicoletti, Francesco Patti, Napoleone Ferrara, Pier Luigi Canonico, Giovanni Giammona, Daniele Filippo Condorelli, Umberto Scapagnini

Research output: Contribution to journalArticlepeer-review


The comparative effects of a 10 day estrogen treatment and estrogen independent hyperprolactinemia on nigral and striatal glutamic acid decarboxylase (GAD, EC activity were investigated in male rats. Data obtained show that estrogen treatment decreases GAD activity in substantia nigra, while an increase was observed in conditions of hyperprolactinemia induced by modulation of strio-nigral GABAergic system by estrogens and prolactin is suggested.

Original languageEnglish
Pages (from-to)238-241
Number of pages4
JournalBrain Research
Issue number1
Publication statusPublished - Jan 28 1982


  • corpus striatum
  • estrogens
  • GAD activity
  • prolactin
  • substantia nigra

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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