Comparative effects of ramipril and nitrendipine on albuminuria in hypertensive patients with non-insulin dependent diabetes mellitus and impaired renal function

R. Fogari, A. Zoppi, C. Pasotti, A. Mugellini, P. Lusardi, P. Lazzari, L. Corradi

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to compare the effects of ramipril and nitrendipine on urinary albumin excretion (UAE) in hypertensive patients with non-insulin-dependent diabetes mellitus (NIDDM) and impaired renal function. Forty patients with mild hypertension with NIDDM and persistent albuminuria (> 300 mg/24h) were studied. After a 3-week run-in period on placebo, patients were randomly treated with ramipril 5 mg once daily or nitrendipine 20 mg once daily for 6 months, according to a double-blind design. Blood pressure (BP), UAE, creatinine clearance and glycosilated haemoglobin were evaluated at the end of the placebo period and after 1, 3 and 6 months of active treatment. Both ramipril and nitrendipine significantly lowered BP values without affecting glucose homeostasis and renal function. Despite equivalent BP control, only ramipril afforded a significant reduction in UAE, thus suggesting that the antiproteinuric effect of ramipril is at least partially independent of its anti-hypertensive effect.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalJournal of Human Hypertension
Volume9
Issue number2
Publication statusPublished - 1995

Keywords

  • D. mellitus
  • Hypertension
  • Nitrendipine
  • Proteinuria
  • Ramipril

ASJC Scopus subject areas

  • Internal Medicine

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