Comparative effects on intraocular pressure between systemic and topical carbonic anhydrase inhibitors: A clinical masked, cross-over study

M. Centofanti, G. L. Manni, D. Napoli, M. G. Bucci

Research output: Contribution to journalArticle

Abstract

The aims of the following study were to compare the efficacy of Dorzolamide 1% eye drops with systemic Acetazolamide on the ocular pressure diurnal curve in patients with maximal medical therapy. Three ocular pressure curve were perfomed in glaucomatous patients, already receiving maximal medical therapy. After a baseline curve, patients were pretreated either with Dorzolamide 1% eye drops or 250 mg Acetazolamide tablets in a double-blind cross-over study. Dorzolamide 1% eye drops and 250 mg Acetazolamide tablets significantly reduced intraocular pressure (IOP) at 2 and 4 h after pretreatment. Both treatments caused a significantly additional decrease of IOP despite maximal medical therapy. Dorzolamide 1% eye drops is as effective as Acetazolamide tablets in reducing the IOP curve. Topical carbonic anhydrase inhibitors may represent an additional and safer treatment for those patients with uncontrolled medical glaucoma.

Original languageEnglish
Pages (from-to)481-485
Number of pages5
JournalPharmacological Research
Volume35
Issue number5
DOIs
Publication statusPublished - May 1997

Keywords

  • Carbonic anhydrase inhibitors
  • Glaucoma
  • Intraocular pressure

ASJC Scopus subject areas

  • Pharmacology

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