Comparative efficacy and safety of 5-day cefaclor and 10-day amoxycillin treatment of group A streptococcal pharyngitis in children

Susanna Esposito, Paola Marchisio, Samantha Bosis, Roberta Droghetti, Roberto Mattina, Nicola Principi

Research output: Contribution to journalArticle


A total of 384 children with group A β-haemolytic streptococcal (GABHS) pharyngitis were randomized to receive either 40 mg/kg/day of cefaclor in two doses for 5 days (192 patients), or 40 mg/kg/day of amoxycillin in three doses for 10 days (192 patients). The signs and symptoms of pharyngitis were recorded and throat cultures were obtained at presentation and on days 6-7, 11-15, 16-20 and 28-35. Patient compliance was significantly higher in the children treated with cefaclor (100 vs. 95.1%; P=0.003). At the end of follow-up, the percentage of clinical success was 91.4% for cefaclor and 91.9% for amoxycillin (P=0.974); bacteriological success was obtained in 85.7 and 89.6% children (P=0.348), respectively. Both treatments were well-tolerated with adverse event rates of 8.3% in the cefaclor group and 9.4% in the amoxcillin group (P=0.857). Our study shows that five days' treatment with cefaclor is as effective and safe as the conventional 10-day course of amoxycillin in the treatment of GABHS pharyngitis, but compliance seems to be significantly greater.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Issue number1
Publication statusPublished - 2002



  • Amoxycillin
  • Cefaclor
  • Children
  • Group A β-haemolytic Streptococcus
  • Pharyngitis
  • Short therapy

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this