Comparative Efficacy of Cyclandelate versus Flunarizine in the Prophylactic Treatment of Migraine

G. Nappi, G. Sandrini, G. Savoini, A. Cavallini, C. de Rysky, G. Micieli

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In a double-blind, parallel-group randomised trial of 3 months’ duration, the efficacy of cyclandelate 800mg twice daily in migraine prophylaxis was compared with that of flunarizine 5mg daily in 40 patients. In comparison with placebo and baseline values, both drugs significantly relieved symptoms of migraine as assessed by indices of pain total index, headache index, analgesic consumption and number of migraine days. Patients taking flunarizine experienced side effects such as drowsiness, weight gain and asthenia, while the most common complaint reported with cyclandelate was gastric upset. These results suggest that cyclandelate may be a useful alternative in migraine pro-phylaxis.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalDrugs
Volume33
Issue number2
DOIs
Publication statusPublished - 1987

Fingerprint

Cyclandelate
Flunarizine
Migraine Disorders
Asthenia
Analgesics
Sleep Stages
Therapeutics
Weight Gain
Headache
Stomach
Placebos
Pain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Comparative Efficacy of Cyclandelate versus Flunarizine in the Prophylactic Treatment of Migraine. / Nappi, G.; Sandrini, G.; Savoini, G.; Cavallini, A.; de Rysky, C.; Micieli, G.

In: Drugs, Vol. 33, No. 2, 1987, p. 103-109.

Research output: Contribution to journalArticle

Nappi, G. ; Sandrini, G. ; Savoini, G. ; Cavallini, A. ; de Rysky, C. ; Micieli, G. / Comparative Efficacy of Cyclandelate versus Flunarizine in the Prophylactic Treatment of Migraine. In: Drugs. 1987 ; Vol. 33, No. 2. pp. 103-109.
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