Comparative Efficacy of Cyclandelate versus Flunarizine in the Prophylactic Treatment of Migraine

G. Nappi, G. Sandrini, G. Savoini, A. Cavallini, C. de Rysky, G. Micieli

Research output: Contribution to journalArticle


In a double-blind, parallel-group randomised trial of 3 months’ duration, the efficacy of cyclandelate 800mg twice daily in migraine prophylaxis was compared with that of flunarizine 5mg daily in 40 patients. In comparison with placebo and baseline values, both drugs significantly relieved symptoms of migraine as assessed by indices of pain total index, headache index, analgesic consumption and number of migraine days. Patients taking flunarizine experienced side effects such as drowsiness, weight gain and asthenia, while the most common complaint reported with cyclandelate was gastric upset. These results suggest that cyclandelate may be a useful alternative in migraine pro-phylaxis.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
Issue number2
Publication statusPublished - 1987


ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology
  • Health, Toxicology and Mutagenesis

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