Comparative efficacy of valsartan and olmesartan in mild-to-moderate hypertension: Results of 24-hour ambulatory blood pressure monitoring

Maurizio Destro, Rossana Scabrosetti, Alessandro Vanasia, Amedeo Mugellini

Research output: Contribution to journalArticle

Abstract

The aim of this prospective, randomized, open-label, blinded endpoint (PROBE) study was to compare the antihypertensive efficacy of 2 angiotensin II (AII) receptor antagonists with different pharmacologic profiles, valsartan and olmesartan, in patients with mild-to-moderate essential hypertension. After an initial 2-week washout period, 114 patients (64 men, 50 women; aged 35-70 years) were randomly assigned to receive valsartan 160 mg or olmesartan 20 mg once daily for 8 weeks. After the washout period and after 2 and 8 weeks of treatment, 24-hour ambulatory blood pressure monitoring (ABPM) was performed using a noninvasive device, and casual blood pressure (BP) and heart rate were measured. Both olmesartan and valsartan had a clear-cut antihypertensive effect. However, significantly earlier and more pronounced antihypertensive activity was achieved with valsartan than with olmesartan, as demonstrated by (1) significantly lower 24-hour, daytime, and nighttime ABPM values after 2 weeks with valsartan (P

Original languageEnglish
Pages (from-to)32-43
Number of pages12
JournalAdvances in Therapy
Volume22
Issue number1
Publication statusPublished - Jan 2005

Keywords

  • Ambulatory blood pressure monitoring
  • Hypertension
  • Olmesartan
  • Valsartan

ASJC Scopus subject areas

  • Medicine(all)

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