Comparative efficiency of contrast-enhanced colour Doppler ultrasound targeted versus systematic biopsy for prostate cancer detection

Michael Josef Mitterberger, Friedrich Aigner, Wolfgang Horninger, Hanno Ulmer, Silvio Cavuto, Ethan J. Halpern, Ferdinand Frauscher

Research output: Contribution to journalArticle

Abstract

Objective: To compare the efficiency of contrast-enhanced colour Doppler ultrasound (CECD-US) targeted biopsy versus systematic biopsy (SB) for PCa detection in 1,776 men. Methods: Retrospective, single-centre, diagnostic accuracy study from 2002 until 2006 in 1,776 male volunteers with a serum total PSA of 1.25 ng/ml or greater. In each patient five CECD-US targeted biopsies were performed in hypervascular areas in the peripheral zone during intravenous injection of a second-generation microbubble US contrast agent. Subsequently, another examiner performed ten SBs. The PCa detection rates for the two techniques were compared. Results: Of 1,776 patients, cancer was detected in 559 patients (31%), including 476 of the 1,776 patients (27%) with CECD-US and 410 (23%) with SB (p∈

Original languageEnglish
Pages (from-to)2791-2796
Number of pages6
JournalEuropean Radiology
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Contrast agents
  • Prostate biopsy
  • Prostate cancer
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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