Abstract
The analgesic activity of Ketorolac tromethamine suppository 30 mg. vs Ketoprofen suppository 100 mg. has been studied in patients affected by acute low back pain, in a randomized, blind observer study. 60 patients were randomly assigned to treatment, obtaining two groups of 30 patients treated b.i.d. for 5 days. The two drugs resulted equally effective in pain reduction and pain relief. Ketorolac showed a quicker and higher analgesic acitivity, which was statistically significant within 2 hrs, while Ketoprofen did so only after 4 hrs. The same applied to effects on functional impairment. The two drugs resulted equally effective on a 5-days basis, but Ketorolac induced a significant two improvement of functional activities already at the 2nd day, while Ketoprofen obtained a similar result only after 5 days. Local and systemic tolerability of both drugs resulted highly satisfactory. In conclusion, our data show that Ketorolac suppository is effective in treating pain related to acute low back pain and has a very interesting quick onset of action.
| Original language | Italian |
|---|---|
| Pages (from-to) | 82-88 |
| Number of pages | 7 |
| Journal | Ortopedia e Traumatologia Oggi |
| Volume | 14 |
| Issue number | 2 |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Surgery
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VALUTAZIONE COMPARATIVA DELL'EFFETTO DI KETOROLAC SUPPOSTE 30 MG IN CONFRONTO A KETOPROFENE SUPPOSTE 100 MG IN PAZIENTI AFFETTI DA LOMBALGIA ACUTA. / Torri, G.; Vignati, C.; Solimeno, P. L.; Lovato, M.; Russo, A.; Curti, M. E.
In: Ortopedia e Traumatologia Oggi, Vol. 14, No. 2, 1994, p. 82-88.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - VALUTAZIONE COMPARATIVA DELL'EFFETTO DI KETOROLAC SUPPOSTE 30 MG IN CONFRONTO A KETOPROFENE SUPPOSTE 100 MG IN PAZIENTI AFFETTI DA LOMBALGIA ACUTA
AU - Torri, G.
AU - Vignati, C.
AU - Solimeno, P. L.
AU - Lovato, M.
AU - Russo, A.
AU - Curti, M. E.
PY - 1994
Y1 - 1994
N2 - The analgesic activity of Ketorolac tromethamine suppository 30 mg. vs Ketoprofen suppository 100 mg. has been studied in patients affected by acute low back pain, in a randomized, blind observer study. 60 patients were randomly assigned to treatment, obtaining two groups of 30 patients treated b.i.d. for 5 days. The two drugs resulted equally effective in pain reduction and pain relief. Ketorolac showed a quicker and higher analgesic acitivity, which was statistically significant within 2 hrs, while Ketoprofen did so only after 4 hrs. The same applied to effects on functional impairment. The two drugs resulted equally effective on a 5-days basis, but Ketorolac induced a significant two improvement of functional activities already at the 2nd day, while Ketoprofen obtained a similar result only after 5 days. Local and systemic tolerability of both drugs resulted highly satisfactory. In conclusion, our data show that Ketorolac suppository is effective in treating pain related to acute low back pain and has a very interesting quick onset of action.
AB - The analgesic activity of Ketorolac tromethamine suppository 30 mg. vs Ketoprofen suppository 100 mg. has been studied in patients affected by acute low back pain, in a randomized, blind observer study. 60 patients were randomly assigned to treatment, obtaining two groups of 30 patients treated b.i.d. for 5 days. The two drugs resulted equally effective in pain reduction and pain relief. Ketorolac showed a quicker and higher analgesic acitivity, which was statistically significant within 2 hrs, while Ketoprofen did so only after 4 hrs. The same applied to effects on functional impairment. The two drugs resulted equally effective on a 5-days basis, but Ketorolac induced a significant two improvement of functional activities already at the 2nd day, while Ketoprofen obtained a similar result only after 5 days. Local and systemic tolerability of both drugs resulted highly satisfactory. In conclusion, our data show that Ketorolac suppository is effective in treating pain related to acute low back pain and has a very interesting quick onset of action.
KW - acute low back pain
KW - analgesia
KW - ketorolac tromethamine
UR - http://www.scopus.com/inward/record.url?scp=0027935563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027935563&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0027935563
VL - 14
SP - 82
EP - 88
JO - Ortopedia e Traumatologia Oggi
JF - Ortopedia e Traumatologia Oggi
SN - 0392-1417
IS - 2
ER -