Abstract
Shc family of adaptor molecules has been demonstrated to play an important role during the transition from proliferating neural stem cells to postmitotic neurons. Previous studies from our group demonstrated a progressive decrease of ShcA levels occurring in coincidence with the end of embryonic neurogenesis and neuronal maturation, being ShcB and ShcC the major Shc molecules expressed in the mature brain. A growing body of evidence indicates that ShcB and ShcC are neuronal specific molecules exerting important roles in neuronal survival and phenotypic stability thus becoming potential attracting target molecules for development of drugs for interfering with brain demises. Here, we examine the expression pattern of ShcB and ShcC in neuronal populations composing the adult central and peripheral nervous system, in order to better elucidate their roles in vivo. We found a heterogeneous and peculiar presence and subcellular localization of ShcB and ShcC in specific neuronal populations, enlightening a potential specific requirement of these two molecules in the survival/maintenance of defined neuronal subtypes.
| Original language | English |
|---|---|
| Pages (from-to) | 105-115 |
| Number of pages | 11 |
| Journal | Neuroscience |
| Volume | 133 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 |
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Keywords
- Adult brain
- Mature neurons
- Neuronal survival
- Shc molecules
- Signal transduction
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Comparative expression profiles of ShcB and ShcC phosphotyrosine adapter molecules in the adult brain. / Ponti, G.; Conti, L.; Cataudella, T.; Zuccato, C.; Magrassi, L.; Rossi, F.; Bonfanti, L.; Cattaneo, E.
In: Neuroscience, Vol. 133, No. 1, 2005, p. 105-115.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative expression profiles of ShcB and ShcC phosphotyrosine adapter molecules in the adult brain
AU - Ponti, G.
AU - Conti, L.
AU - Cataudella, T.
AU - Zuccato, C.
AU - Magrassi, L.
AU - Rossi, F.
AU - Bonfanti, L.
AU - Cattaneo, E.
PY - 2005
Y1 - 2005
N2 - Shc family of adaptor molecules has been demonstrated to play an important role during the transition from proliferating neural stem cells to postmitotic neurons. Previous studies from our group demonstrated a progressive decrease of ShcA levels occurring in coincidence with the end of embryonic neurogenesis and neuronal maturation, being ShcB and ShcC the major Shc molecules expressed in the mature brain. A growing body of evidence indicates that ShcB and ShcC are neuronal specific molecules exerting important roles in neuronal survival and phenotypic stability thus becoming potential attracting target molecules for development of drugs for interfering with brain demises. Here, we examine the expression pattern of ShcB and ShcC in neuronal populations composing the adult central and peripheral nervous system, in order to better elucidate their roles in vivo. We found a heterogeneous and peculiar presence and subcellular localization of ShcB and ShcC in specific neuronal populations, enlightening a potential specific requirement of these two molecules in the survival/maintenance of defined neuronal subtypes.
AB - Shc family of adaptor molecules has been demonstrated to play an important role during the transition from proliferating neural stem cells to postmitotic neurons. Previous studies from our group demonstrated a progressive decrease of ShcA levels occurring in coincidence with the end of embryonic neurogenesis and neuronal maturation, being ShcB and ShcC the major Shc molecules expressed in the mature brain. A growing body of evidence indicates that ShcB and ShcC are neuronal specific molecules exerting important roles in neuronal survival and phenotypic stability thus becoming potential attracting target molecules for development of drugs for interfering with brain demises. Here, we examine the expression pattern of ShcB and ShcC in neuronal populations composing the adult central and peripheral nervous system, in order to better elucidate their roles in vivo. We found a heterogeneous and peculiar presence and subcellular localization of ShcB and ShcC in specific neuronal populations, enlightening a potential specific requirement of these two molecules in the survival/maintenance of defined neuronal subtypes.
KW - Adult brain
KW - Mature neurons
KW - Neuronal survival
KW - Shc molecules
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=18844363974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18844363974&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2005.02.014
DO - 10.1016/j.neuroscience.2005.02.014
M3 - Article
C2 - 15893635
AN - SCOPUS:18844363974
VL - 133
SP - 105
EP - 115
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 1
ER -