Comparative genomic hybridisation in malignant deciduoid mesothelioma

A. Scattone, A. Pennella, M. Gentile, M. Musti, P. Nazzaro, A. L. Buonadonna, A. Marzullo, D. Cavone, L. Pollice, G. Serio

Research output: Contribution to journalArticle

Abstract

Background: Malignant deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. This tumour generally has poor prognosis, and can be asbestos related. Aim: To identify peculiar genetic changes responsible for critical phases in pathogenesis of malignant deciduoid mesothelioma and their prognostic relevance. Methods: Comparative genomic hybridisation was carried out in six cases of malignant pleural deciduoid mesothelioma, four sporadic and two familial. All cases were found to be asbestos related. Four patients died during follow-up and the mean survival was 29.5 (SD 14.2, range 12-43) months. Results: Genetic abnormalities were found in all the tumour tissues, the most frequent being chromosomal gains at 1 p, 12q, 17, 8q, 19 and 20 and losses at 13q, 6q and 9p. Survival was found to be longer in those patients who presented a smaller number of losses (≤ 2) in the tumorous chromosomes. Conclusions: Although numerous genetic changes are presented by deciduoid mesotheliomas, certain chromosomal regions are preferentially affected. The clinical outcome for this mesothelioma subtype is predicted by the number of losses.

Original languageEnglish
Pages (from-to)764-769
Number of pages6
JournalJournal of Clinical Pathology
Volume59
Issue number7
DOIs
Publication statusPublished - Jul 2006

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Comparative genomic hybridisation in malignant deciduoid mesothelioma'. Together they form a unique fingerprint.

  • Cite this

    Scattone, A., Pennella, A., Gentile, M., Musti, M., Nazzaro, P., Buonadonna, A. L., Marzullo, A., Cavone, D., Pollice, L., & Serio, G. (2006). Comparative genomic hybridisation in malignant deciduoid mesothelioma. Journal of Clinical Pathology, 59(7), 764-769. https://doi.org/10.1136/jcp.2005.026435