TY - JOUR
T1 - Comparative genomic hybridisation in malignant deciduoid mesothelioma
AU - Scattone, A.
AU - Pennella, A.
AU - Gentile, M.
AU - Musti, M.
AU - Nazzaro, P.
AU - Buonadonna, A. L.
AU - Marzullo, A.
AU - Cavone, D.
AU - Pollice, L.
AU - Serio, G.
PY - 2006/7
Y1 - 2006/7
N2 - Background: Malignant deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. This tumour generally has poor prognosis, and can be asbestos related. Aim: To identify peculiar genetic changes responsible for critical phases in pathogenesis of malignant deciduoid mesothelioma and their prognostic relevance. Methods: Comparative genomic hybridisation was carried out in six cases of malignant pleural deciduoid mesothelioma, four sporadic and two familial. All cases were found to be asbestos related. Four patients died during follow-up and the mean survival was 29.5 (SD 14.2, range 12-43) months. Results: Genetic abnormalities were found in all the tumour tissues, the most frequent being chromosomal gains at 1 p, 12q, 17, 8q, 19 and 20 and losses at 13q, 6q and 9p. Survival was found to be longer in those patients who presented a smaller number of losses (≤ 2) in the tumorous chromosomes. Conclusions: Although numerous genetic changes are presented by deciduoid mesotheliomas, certain chromosomal regions are preferentially affected. The clinical outcome for this mesothelioma subtype is predicted by the number of losses.
AB - Background: Malignant deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. This tumour generally has poor prognosis, and can be asbestos related. Aim: To identify peculiar genetic changes responsible for critical phases in pathogenesis of malignant deciduoid mesothelioma and their prognostic relevance. Methods: Comparative genomic hybridisation was carried out in six cases of malignant pleural deciduoid mesothelioma, four sporadic and two familial. All cases were found to be asbestos related. Four patients died during follow-up and the mean survival was 29.5 (SD 14.2, range 12-43) months. Results: Genetic abnormalities were found in all the tumour tissues, the most frequent being chromosomal gains at 1 p, 12q, 17, 8q, 19 and 20 and losses at 13q, 6q and 9p. Survival was found to be longer in those patients who presented a smaller number of losses (≤ 2) in the tumorous chromosomes. Conclusions: Although numerous genetic changes are presented by deciduoid mesotheliomas, certain chromosomal regions are preferentially affected. The clinical outcome for this mesothelioma subtype is predicted by the number of losses.
UR - http://www.scopus.com/inward/record.url?scp=33745887806&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745887806&partnerID=8YFLogxK
U2 - 10.1136/jcp.2005.026435
DO - 10.1136/jcp.2005.026435
M3 - Article
C2 - 16569690
AN - SCOPUS:33745887806
VL - 59
SP - 764
EP - 769
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 7
ER -