Among melanocytic lesions it is often difficult to distinguish between malignant and benign lesions. Our purpose was to verify the usefulness of monoclonal antibodies against melanocytic associated antigens in differential diagnosis of melanocytic lesions. One hundred melanocytic lesions (10 junctional nevi, 10 compound nevi, 10 intradermal nevi, 10 Spitz's nevi, 10 cellular blu nevi, 10 common blu nevi, 10 displastic junctional nevi, 10 malignant lentigo, 10 superficial spreading melanoma, 10 melanoma from nevi), embedded in paraffin, have been immunostained with three different monoclonal antibodies: S100, HMB-45, NKI-C3 (immunoperoxidase technic). The results have confirmed that S100 is a good marker of dermal melanocytes and of Spitz's spindle melanocytes; the HMB-45 is particularly useful for neoplastic melanocytes, instead NKI-C3 is useful for junctional 'activated' melanocytes of displastic nevi and of malignant lentigo. According to litterature we conclude that doesn't exist an exclusive marker of neoplastic melanocytes, but the combinated use of different monoclonal antibodies helps patologist in a better diagnosis.
|Translated title of the contribution||Comparative immunohistochemical study with S100, HMB-45 and NKI-C3 of 100 melanocytic lesions|
|Number of pages||5|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1994|
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