Comparative in-vitro activity of moxifloxacin, penicillin, ceftriaxone and ciprofloxacin against pneumococci isolated from meningitis

Agapito Tarasi, Alessandro Capone, David Tarasi, Marco Cassone, Gianluca Bianco, Mario Venditti

Research output: Contribution to journalArticle

Abstract

Minimum inhibitory concentrations of penicillin, ceftriaxone, ciprofloxacin, and moxifloxacin (BAY 12-8039), a new 8-methoxyquinolone, were determined for 60 cerebrospinal fluid isolates of Streptococcus pneumoniae collected during January 1997-April 1998 at Italian medical centres. Three reference isolates with predetermined MIC values (two penicillin- and multidrug-resistant isolates, one uniformly susceptible to all antibiotics) were also tested with the same antibiotics. The MIC90, of penicillin was ≤ 0.03 mg/L (range ≤ 0.03-2 mg/L), of ceftriaxone 0.06 mg/L (range ≤ 0.03-0.5 mg/L), of ciprofloxacin 2 mg/L (range 0.5-8 mg/L) and of moxifloxacin 0.06 mg/L (range 0.03-0.12 mg/L). Moxifloxacin was effective against all the penicillin-resistant isolates tested, with an MIC of 0.06 mg/L. Moxifloxacin was 32-fold more active than ciprofloxacin and was not affected by penicillin and cephalosporin resistance. These results indicate that moxifloxacin could be useful for the treatment of both penicillin-sensitive and -resistant S. pneumoniae meningitis.

Original languageEnglish
Pages (from-to)833-835
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume43
Issue number6
DOIs
Publication statusPublished - 1999

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Ceftriaxone
Ciprofloxacin
Streptococcus pneumoniae
Meningitis
Penicillins
Cephalosporin Resistance
Pneumococcal Meningitis
Anti-Bacterial Agents
Penicillin Resistance
Microbial Sensitivity Tests
Cerebrospinal Fluid
moxifloxacin
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

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Comparative in-vitro activity of moxifloxacin, penicillin, ceftriaxone and ciprofloxacin against pneumococci isolated from meningitis. / Tarasi, Agapito; Capone, Alessandro; Tarasi, David; Cassone, Marco; Bianco, Gianluca; Venditti, Mario.

In: Journal of Antimicrobial Chemotherapy, Vol. 43, No. 6, 1999, p. 833-835.

Research output: Contribution to journalArticle

Tarasi, Agapito ; Capone, Alessandro ; Tarasi, David ; Cassone, Marco ; Bianco, Gianluca ; Venditti, Mario. / Comparative in-vitro activity of moxifloxacin, penicillin, ceftriaxone and ciprofloxacin against pneumococci isolated from meningitis. In: Journal of Antimicrobial Chemotherapy. 1999 ; Vol. 43, No. 6. pp. 833-835.
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