Comparative in vitro study on a ultra-high roughness and dense titanium coating

Veronica Borsari, Gianluca Giavaresi, Milena Fini, Paola Torricelli, Matilde Tschon, Roberto Chiesa, Loris Chiusoli, Armando Salito, Andreas Volpert, Roberto Giardino

Research output: Contribution to journalArticle


A new implant surface has been developed with the purpose of avoiding as much stress shielding as possible, and thus prolong the prosthesis lifespan. The aim of this study was to investigate the in vitro effect of this new ultra-high roughness and dense Titanium (Ti) surface (PG60, Ra=74μm) in comparison with medium (TI01, Ra=18μm) and high (TI60, R a=40μm) roughness and open porous coatings; all the coatings were obtained by vacuum plasma spraying. MG63 osteoblast-like cells were seeded on the tested materials and polystyrene, as control, for 3 and 7 days. Cells proliferated on the material surfaces similarly to the control. Alkaline phosphatase activity had lower values for TI60 than TI01 (p

Original languageEnglish
Pages (from-to)4948-4955
Number of pages8
Issue number24
Publication statusPublished - Aug 2005



  • Cell proliferation
  • Cytokines
  • Osteoblast
  • Plasma spraying
  • Surface roughness
  • Titanium

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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