Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone)

E. Perucca, R. Grimaldi, G. Ruberto, C. Gelmi, F. Trimarchi, A. Crema

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The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.

Original languageEnglish
Pages (from-to)729-730
Number of pages2
JournalEuropean Journal of Clinical Pharmacology
Issue number6
Publication statusPublished - Nov 1986



  • barbexaclone
  • bioavailability
  • healthy volunteers
  • pharmacokinetics
  • phenobarbital
  • propylhexedrine salt

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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