Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone)

E. Perucca, R. Grimaldi, G. Ruberto, C. Gelmi, F. Trimarchi, A. Crema

Research output: Contribution to journalArticle

Abstract

The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.

Original languageEnglish
Pages (from-to)729-730
Number of pages2
JournalEuropean Journal of Clinical Pharmacology
Volume29
Issue number6
DOIs
Publication statusPublished - Nov 1986

    Fingerprint

Keywords

  • barbexaclone
  • bioavailability
  • healthy volunteers
  • pharmacokinetics
  • phenobarbital
  • propylhexedrine salt

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this