Comparative mapping of a gorilla-derived alpha satellite DNA clone on great ape and human chromosomes

Antonio Baldini, Dorothy A. Miller, Viji Shridhar, Mariano Rocchi, Orlando J. Miller, David C. Ward

Research output: Contribution to journalArticle

Abstract

We have isolated an alpha satellite DNA clone, pG3.9, from gorilla DNA. Fluorescence in situ hybridization on banded chromosomes under high stringency conditions revealed that pG3.9 identifies homologous sequences at the centromeric region of ten gorilla chromosomes, and, with few exceptions, also recognizes the homologous chromosomes in human. A pG3.9-like alphoid DNA is present on a larger number of orangutan chromosomes, but, in contrast, is present on only tow chromosomes in the chimpanzee. These results show that the chromosomal subsets of related alpha satellite DNA sequences may undergo different patterns of evolution.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalChromosoma
Volume101
Issue number2
DOIs
Publication statusPublished - Nov 1991

ASJC Scopus subject areas

  • Genetics

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    Baldini, A., Miller, D. A., Shridhar, V., Rocchi, M., Miller, O. J., & Ward, D. C. (1991). Comparative mapping of a gorilla-derived alpha satellite DNA clone on great ape and human chromosomes. Chromosoma, 101(2), 109-114. https://doi.org/10.1007/BF00357060