Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure

Serge Masson, Tarcisio Vago, Gabriella Baldi, Monica Salio, Noeleen De Angelis, Enrico Nicolis, Aldo P. Maggioni, Roberto Latini, Guido Norbiato, Maurizio Bevilacqua

Research output: Contribution to journalArticlepeer-review

Abstract

It is not clear whether brain natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) is superior as a diagnostic and prognostic indicator in cardiac diseases. Here, we compare the clinical correlations of both peptides in a population of 92 ambulatory patients with heart failure, using a well-established immunoradiometric assay (IRMA) for BNP and an automated electrochemiluminescence immunoassay for NT-proBNP. The analytical correlation between the two peptides was satisfactory over a wide range of concentrations (1-686 pM for BNP) with the equation: NT-proBNP = 3.48 x BNP -19 and a correlation coefficient r2=0.94. In addition, the concentration of both peptides increased in a similar fashion according to the severity of the disease New York Heart Association (NYHA) functional class, left ventricular ejection fraction, etiology) and age; for instance, the ratios between median levels measured in NYHA class III vs. class II patients were comparable for BNP (383 vs. 16 pM, ratio 24) and NT-proBNP (1306 vs. 57 pM, ratio 23). We conclude that N-terminal proBNP, as assayed in the present study, correlates equally to BNP with clinical variables in patients with heart failure.

Original languageEnglish
Pages (from-to)761-763
Number of pages3
JournalClinical Chemistry and Laboratory Medicine
Volume40
Issue number8
DOIs
Publication statusPublished - 2002

Keywords

  • Brain natriuretic peptide
  • Heart failure
  • N-terminal pro-brain natriuretic peptide

ASJC Scopus subject areas

  • Clinical Biochemistry

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