Abstract
It is not clear whether brain natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) is superior as a diagnostic and prognostic indicator in cardiac diseases. Here, we compare the clinical correlations of both peptides in a population of 92 ambulatory patients with heart failure, using a well-established immunoradiometric assay (IRMA) for BNP and an automated electrochemiluminescence immunoassay for NT-proBNP. The analytical correlation between the two peptides was satisfactory over a wide range of concentrations (1-686 pM for BNP) with the equation: NT-proBNP = 3.48 x BNP -19 and a correlation coefficient r2=0.94. In addition, the concentration of both peptides increased in a similar fashion according to the severity of the disease New York Heart Association (NYHA) functional class, left ventricular ejection fraction, etiology) and age; for instance, the ratios between median levels measured in NYHA class III vs. class II patients were comparable for BNP (383 vs. 16 pM, ratio 24) and NT-proBNP (1306 vs. 57 pM, ratio 23). We conclude that N-terminal proBNP, as assayed in the present study, correlates equally to BNP with clinical variables in patients with heart failure.
| Original language | English |
|---|---|
| Pages (from-to) | 761-763 |
| Number of pages | 3 |
| Journal | Clinical Chemistry and Laboratory Medicine |
| Volume | 40 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Brain natriuretic peptide
- Heart failure
- N-terminal pro-brain natriuretic peptide
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure. / Masson, Serge; Vago, Tarcisio; Baldi, Gabriella; Salio, Monica; De Angelis, Noeleen; Nicolis, Enrico; Maggioni, Aldo P.; Latini, Roberto; Norbiato, Guido; Bevilacqua, Maurizio.
In: Clinical Chemistry and Laboratory Medicine, Vol. 40, No. 8, 2002, p. 761-763.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure
AU - Masson, Serge
AU - Vago, Tarcisio
AU - Baldi, Gabriella
AU - Salio, Monica
AU - De Angelis, Noeleen
AU - Nicolis, Enrico
AU - Maggioni, Aldo P.
AU - Latini, Roberto
AU - Norbiato, Guido
AU - Bevilacqua, Maurizio
PY - 2002
Y1 - 2002
N2 - It is not clear whether brain natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) is superior as a diagnostic and prognostic indicator in cardiac diseases. Here, we compare the clinical correlations of both peptides in a population of 92 ambulatory patients with heart failure, using a well-established immunoradiometric assay (IRMA) for BNP and an automated electrochemiluminescence immunoassay for NT-proBNP. The analytical correlation between the two peptides was satisfactory over a wide range of concentrations (1-686 pM for BNP) with the equation: NT-proBNP = 3.48 x BNP -19 and a correlation coefficient r2=0.94. In addition, the concentration of both peptides increased in a similar fashion according to the severity of the disease New York Heart Association (NYHA) functional class, left ventricular ejection fraction, etiology) and age; for instance, the ratios between median levels measured in NYHA class III vs. class II patients were comparable for BNP (383 vs. 16 pM, ratio 24) and NT-proBNP (1306 vs. 57 pM, ratio 23). We conclude that N-terminal proBNP, as assayed in the present study, correlates equally to BNP with clinical variables in patients with heart failure.
AB - It is not clear whether brain natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) is superior as a diagnostic and prognostic indicator in cardiac diseases. Here, we compare the clinical correlations of both peptides in a population of 92 ambulatory patients with heart failure, using a well-established immunoradiometric assay (IRMA) for BNP and an automated electrochemiluminescence immunoassay for NT-proBNP. The analytical correlation between the two peptides was satisfactory over a wide range of concentrations (1-686 pM for BNP) with the equation: NT-proBNP = 3.48 x BNP -19 and a correlation coefficient r2=0.94. In addition, the concentration of both peptides increased in a similar fashion according to the severity of the disease New York Heart Association (NYHA) functional class, left ventricular ejection fraction, etiology) and age; for instance, the ratios between median levels measured in NYHA class III vs. class II patients were comparable for BNP (383 vs. 16 pM, ratio 24) and NT-proBNP (1306 vs. 57 pM, ratio 23). We conclude that N-terminal proBNP, as assayed in the present study, correlates equally to BNP with clinical variables in patients with heart failure.
KW - Brain natriuretic peptide
KW - Heart failure
KW - N-terminal pro-brain natriuretic peptide
UR - http://www.scopus.com/inward/record.url?scp=18544389492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18544389492&partnerID=8YFLogxK
U2 - 10.1515/CCLM.2002.130
DO - 10.1515/CCLM.2002.130
M3 - Article
C2 - 12392300
AN - SCOPUS:18544389492
VL - 40
SP - 761
EP - 763
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
SN - 1434-6621
IS - 8
ER -