Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

T. Ottone, L. Cicconi, S. K. Hasan, S. Lavorgna, M. Divona, M. T. Voso, E. Montefusco, L. Melillo, E. Barragán, U. Platzbecker, L. Giannì, M. Hubmann, M. Pagoni, S. Amadori, F. Lo-Coco

Research output: Contribution to journalArticlepeer-review


Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

Original languageEnglish
Pages (from-to)474-478
Number of pages5
JournalLeukemia Research
Issue number4
Publication statusPublished - Apr 2012


  • Acute Promyelocytic Leukemia
  • DNMT3A mutation
  • IDHs mutation
  • TET2 mutation
  • Therapy-related leukemia

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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