Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: A retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT)

M. Aoudjhane, M. Labopin, N. C. Gorin, A. Shimoni, T. Ruutu, H. J. Kolb, F. Frassoni, J. M. Boiron, J. L. Yin, J. Finke, H. Shouten, D. Blaise, M. Falda, A. A. Fauser, J. Esteve, E. Polge, S. Slavin, D. Niederwieser, A. Nagler, Vanderson RochaP. Galiene, M. Petrini, G. Schlimok, A. Buzyn, E. Ovali, A. Gratwohl, R. Willemze, D. Bunjes, J. M. Goldman, N. Jacobsen, E. Gluckman, U. Schanz, M. A. Boogaerts, P. Ljungman, E. Montserrat, D. Bron, M. Potter, A. Bacigalupo, R. Powles, B. Rio, L. Kanz, A. H. Goldstone, K. Remes, H. T. Greinix, J. M. Davies, D. Blaise, M. Falda, F. Mandelli, J. Y. Cahn, A. Ferrant, L. Brinch, J. M. Fernández-Ranada, A. Torres Gomez, L. F. Verdonck, M. Baccarani, A. Iriondo, I. Franklin, V. Rizzoli, J. J. Cornelissen, H. Van den Berg, C. Cordonnier, J. L. Harousseau, D. L. Barnard, T. Littlewood, H. A. Horst, S. McCann, S. Slavin, U. W. Schaefer, J. Sierra, B. Chapuis, V. Leblond, F. Guilhot, G. Lambertenghi Deliliers, B. Simonsson, J. Reiffers, J. J. Sotto, G. Gastl, J. O. Bay, G. L. Jackson, J. García-Conde, S. Lenhoff, E. P. Alessandrino, I. Majolino, T. Izzi, M. Brune, P. Pimentel, W. Siegert, E. Morra, B. Hertenstein, D. Hoelzer, P. Coser, M. Abecasis, B. Labar, A. K. Burnett, A. Bosi, G. Leone, W. Linkesch, R. Schwerdtfeger, F. Lauria

Research output: Contribution to journalArticlepeer-review

Abstract

Results of reduced intensity conditioning regimen (RIC) in the HLA identical haematopoietic stem cell transplantation (HSCT) setting have not been compared to those after myeloablative (MA) regimen HSCT in patients with acute myeloblastic leukaemia (AML) over 50 years of age. With this aim, outcomes of 315 RIC were compared with 407 MA HSCT recipients. The majority of RIC was fludarabine-based regimen associated to busulphan (BU) (53%;) or low-dose total body irradiation (24%). Multivariate analyses of outcomes were used adjusting for differences between both groups. The median follow-up was 13 months. Cytogenetics, FAB classification, WBC count at diagnosis and status of the disease at transplant were not statistically different between the two groups. However, RIC patients were older, transplanted more recently, and more frequently with peripheral blood allogeneic stem cells as compared to MA recipients. In multivariate analysis, acute GVHD (II -IV) and transplant-related mortality were significantly decreased (P=0.01 and P-4, respectively) and relapse incidence was significantly higher (P=0.003) after RIC transplantation. Leukaemia-free survival was not statistically different between the two groups. These results may set the grounds for prospective trials comparing RIC with other strategies of treatment in elderly AML.

Original languageEnglish
Pages (from-to)2304-2312
Number of pages9
JournalLeukemia
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Acute myelocytic leukemia
  • Genmoidentical haematopoitic stem cell transplants
  • Reduced intensity preparative regimen

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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