Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line

Flora Cimmino, Daniela Spano, Mario Capasso, Nicola Zambrano, Roberta Russo, Massimo Zollo, Achille Iolascon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which Gβ2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.

Original languageEnglish
Pages (from-to)2550-2564
Number of pages15
JournalJournal of Proteome Research
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 2007

Fingerprint

Tretinoin
Neuroblastoma
Proteomics
Cells
Two-Dimensional Difference Gel Electrophoresis
Local Area Networks
Cell Line
Nuclear Proteins
Electrophoresis
Local area networks
Neurons
Tumors
Neoplasms
Proteins
Gels
Therapeutics
prefoldin

Keywords

  • 2D-DIGE
  • All-trans-retinoic acid
  • Cell line
  • Human neuroblastoma
  • LAN-5
  • Neuroblastoma

ASJC Scopus subject areas

  • Genetics
  • Biotechnology
  • Biochemistry

Cite this

Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line. / Cimmino, Flora; Spano, Daniela; Capasso, Mario; Zambrano, Nicola; Russo, Roberta; Zollo, Massimo; Iolascon, Achille.

In: Journal of Proteome Research, Vol. 6, No. 7, 07.2007, p. 2550-2564.

Research output: Contribution to journalArticle

Cimmino, Flora ; Spano, Daniela ; Capasso, Mario ; Zambrano, Nicola ; Russo, Roberta ; Zollo, Massimo ; Iolascon, Achille. / Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line. In: Journal of Proteome Research. 2007 ; Vol. 6, No. 7. pp. 2550-2564.
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