Comparative Proteomics for the Evaluation of Protein Expression and Modifications in Neurodegenerative Diseases

Antonio Conti, Massimo Alessio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Together with hypothesis-driven approaches, high-throughput differential proteomic analysis performed primarily not only in human cerebrospinal fluid and serum but also on protein content of other tissues (blood cells, muscles, peripheral nerves, etc.) has been used in the last years to investigate neurodegenerative diseases. Even if the goal for these analyses was mainly the discovery of neurodegenerative disorders biomarkers, the characterization of specific posttranslational modifications (PTMs) and the differential protein expression resulted in being very informative to better define the pathological mechanisms. In this chapter are presented and discussed the positive aspects and challenges of the outcomes of some of our investigations on neurological and neurodegenerative disease, in order to highlight the important role of protein PTMs studies in proteomics-based approaches.

Original languageEnglish
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Pages117-152
Number of pages36
Volume121
ISBN (Print)9780128014806
DOIs
Publication statusPublished - 2015

Publication series

NameInternational Review of Neurobiology
Volume121
ISSN (Print)00747742

Keywords

  • Amyotrophic lateral sclerosis
  • Biomarker
  • Cerebrospinal fluid
  • Mass spectrometry
  • Parkinson's disease
  • Posttranslational modifications
  • Two-dimensional electrophoresis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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  • Cite this

    Conti, A., & Alessio, M. (2015). Comparative Proteomics for the Evaluation of Protein Expression and Modifications in Neurodegenerative Diseases. In International Review of Neurobiology (Vol. 121, pp. 117-152). (International Review of Neurobiology; Vol. 121). Academic Press Inc.. https://doi.org/10.1016/bs.irn.2015.05.004