The sera of 142 patients with acute viral hepatitis were examined for the Australia antigen by means of complement fixation, electrosyneresis and latex agglutination. The examination of 222 serum samples confirmed the anticipated greater sensitivity of complement fixation. This technique, alone or in combination with others, demonstrated the Australia antigen in 130 sera, as against 93 positive results for electrosyneresis and 52 for latex agglutination. The best results were observed when using a combination of complement fixation and electrosyneresis, because this might reveal the Australia antigen in a number of samples that were negative to the complement fixation test, and also in several with anticomplementary activity. The incidence of positive sera was identical in patients classified as suffering from serum hepatitis or infectious hepatitis. The Australia antigen was also demonstrated in 49 bile samples and 69 urine samples of the same patients. These fluids seem to be potentially infectious, because the Australia antigen was found in 19 bile and 8 urine samples.
|Translated title of the contribution||Comparative sensitivity of electrosyneresis, complement fixation and latex agglutination in the detection of Australia antigen in 142 patients with acute viral hepatitis|
|Title of host publication||Annali Sclavo - Rivista di Microbiologia e di Immunologia|
|Number of pages||12|
|Publication status||Published - 1973|
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