Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy

Stefania D'Atri, Maria Pia Fuggetta, Gabriella Giganti, Lucio Tentori, Mario Roselli, Corrado Nunziata, Simonetta Pastore, Enzo Bonmassar, Liana De Vecchis

Research output: Contribution to journalArticlepeer-review

Abstract

A good correlation was found between in vivo and in vitro responses of peripheral MNC from breast cancer patients and the NK boosting effect of human βIFN. In vitro immunochemotherapy studies showed that marked antitumor effects were obtained against cultured cancer cells when a widely used chemotherapeutic agent such as 5-FU was combined with nonsensitized spontaneously cytolytic MNC, preactivated in vitro with βIFN. These results suggest that the in vitro susceptibility assay of MNC to IFNs could be used for predicting favorable responses to immunochemotherapy regimens employing IFNs as immunomodulating agents.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalCancer Immunology, Immunotherapy
Volume27
Issue number2
DOIs
Publication statusPublished - Sep 1988

ASJC Scopus subject areas

  • Oncology
  • Immunology
  • Cancer Research

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