Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy

Stefania D'Atri; Maria Pia Fuggetta; Gabriella Giganti; Lucio Tentori; Mario Roselli; Corrado Nunziata; Simonetta Pastore; Enzo Bonmassar; Liana De Vecchis

doi:10.1007/BF00200022

Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy

Stefania D'Atri, Maria Pia Fuggetta, Gabriella Giganti, Lucio Tentori, Mario Roselli, Corrado Nunziata, Simonetta Pastore, Enzo Bonmassar, Liana De Vecchis

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

A good correlation was found between in vivo and in vitro responses of peripheral MNC from breast cancer patients and the NK boosting effect of human βIFN. In vitro immunochemotherapy studies showed that marked antitumor effects were obtained against cultured cancer cells when a widely used chemotherapeutic agent such as 5-FU was combined with nonsensitized spontaneously cytolytic MNC, preactivated in vitro with βIFN. These results suggest that the in vitro susceptibility assay of MNC to IFNs could be used for predicting favorable responses to immunochemotherapy regimens employing IFNs as immunomodulating agents.

Original language	English
Pages (from-to)	163-170
Number of pages	8
Journal	Cancer Immunology, Immunotherapy
Volume	27
Issue number	2
DOIs	https://doi.org/10.1007/BF00200022
Publication status	Published - Sep 1988

ASJC Scopus subject areas

Oncology
Immunology
Cancer Research

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10.1007/BF00200022

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Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy. / D'Atri, Stefania; Fuggetta, Maria Pia; Giganti, Gabriella; Tentori, Lucio; Roselli, Mario; Nunziata, Corrado; Pastore, Simonetta; Bonmassar, Enzo; De Vecchis, Liana.

In: Cancer Immunology, Immunotherapy, Vol. 27, No. 2, 09.1988, p. 163-170.

Research output: Contribution to journal › Article › peer-review

D'Atri, S, Fuggetta, MP, Giganti, G, Tentori, L, Roselli, M, Nunziata, C, Pastore, S, Bonmassar, E & De Vecchis, L 1988, 'Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy', Cancer Immunology, Immunotherapy, vol. 27, no. 2, pp. 163-170. https://doi.org/10.1007/BF00200022

D'Atri, Stefania ; Fuggetta, Maria Pia ; Giganti, Gabriella ; Tentori, Lucio ; Roselli, Mario ; Nunziata, Corrado ; Pastore, Simonetta ; Bonmassar, Enzo ; De Vecchis, Liana. / Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy. In: Cancer Immunology, Immunotherapy. 1988 ; Vol. 27, No. 2. pp. 163-170.

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abstract = "A good correlation was found between in vivo and in vitro responses of peripheral MNC from breast cancer patients and the NK boosting effect of human βIFN. In vitro immunochemotherapy studies showed that marked antitumor effects were obtained against cultured cancer cells when a widely used chemotherapeutic agent such as 5-FU was combined with nonsensitized spontaneously cytolytic MNC, preactivated in vitro with βIFN. These results suggest that the in vitro susceptibility assay of MNC to IFNs could be used for predicting favorable responses to immunochemotherapy regimens employing IFNs as immunomodulating agents.",

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