Immunofluorescent and 'in vitro' biosynthetic techniques were used to study the connections between the maturation process of human lymphocytes that leads to the appearance of actively secreting cells and a possible switchover from IgD to IgM production, both in homogeneous chronic lymphocytic leukemia cell populations and in heterogeneous cell suspensions from tonsils. The results obtained are compatible with the hypothesis that the switchover from IgD to IgM production can be a clonal maturation phenomenon.
|Number of pages||11|
|Journal||Annals of the New York Academy of Sciences|
|Publication status||Published - 1975|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)