Abstract
The 7-nitro group of nitrazepam (1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one) was reduced to the 7-amino derivative and then acetylated to the 7-acetylamino derivative during perfusion of the isolated rat liver. These compounds were present mainly in perfusion fluid, only small amounts were found in bile or liver tissue, homogenized at the end of the experiment. Other metabolites were not detected with the techniques used. Similar results were found with livers of guinea-pigs and rabbits. In contrast, the 7-amino derivative was the final product of nitrazepam metabolism in perfused mouse livers.
| Original language | English |
|---|---|
| Pages (from-to) | 378-382 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1970 |
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Keywords
- Guinea-pig
- Mouse
- Nitrazepam metabolism
- Perfused liver
- Rabbit
- Rat
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Comparative study of nitrazepam metabolism in perfused isolated liver of laboratory animals. / Bartošek, I.; Květina, J.; Guaitani, A.; Garattini, S.
In: European Journal of Pharmacology, Vol. 11, No. 3, 1970, p. 378-382.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative study of nitrazepam metabolism in perfused isolated liver of laboratory animals
AU - Bartošek, I.
AU - Květina, J.
AU - Guaitani, A.
AU - Garattini, S.
PY - 1970
Y1 - 1970
N2 - The 7-nitro group of nitrazepam (1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one) was reduced to the 7-amino derivative and then acetylated to the 7-acetylamino derivative during perfusion of the isolated rat liver. These compounds were present mainly in perfusion fluid, only small amounts were found in bile or liver tissue, homogenized at the end of the experiment. Other metabolites were not detected with the techniques used. Similar results were found with livers of guinea-pigs and rabbits. In contrast, the 7-amino derivative was the final product of nitrazepam metabolism in perfused mouse livers.
AB - The 7-nitro group of nitrazepam (1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one) was reduced to the 7-amino derivative and then acetylated to the 7-acetylamino derivative during perfusion of the isolated rat liver. These compounds were present mainly in perfusion fluid, only small amounts were found in bile or liver tissue, homogenized at the end of the experiment. Other metabolites were not detected with the techniques used. Similar results were found with livers of guinea-pigs and rabbits. In contrast, the 7-amino derivative was the final product of nitrazepam metabolism in perfused mouse livers.
KW - Guinea-pig
KW - Mouse
KW - Nitrazepam metabolism
KW - Perfused liver
KW - Rabbit
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0014717812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014717812&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(70)90014-2
DO - 10.1016/0014-2999(70)90014-2
M3 - Article
C2 - 5477312
AN - SCOPUS:0014717812
VL - 11
SP - 378
EP - 382
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -