Comparative study of nitrazepam metabolism in perfused isolated liver of laboratory animals

I. Bartošek, J. Květina, A. Guaitani, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

The 7-nitro group of nitrazepam (1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one) was reduced to the 7-amino derivative and then acetylated to the 7-acetylamino derivative during perfusion of the isolated rat liver. These compounds were present mainly in perfusion fluid, only small amounts were found in bile or liver tissue, homogenized at the end of the experiment. Other metabolites were not detected with the techniques used. Similar results were found with livers of guinea-pigs and rabbits. In contrast, the 7-amino derivative was the final product of nitrazepam metabolism in perfused mouse livers.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalEuropean Journal of Pharmacology
Volume11
Issue number3
DOIs
Publication statusPublished - 1970

Keywords

  • Guinea-pig
  • Mouse
  • Nitrazepam metabolism
  • Perfused liver
  • Rabbit
  • Rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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