Comparative study of surgical margins in oncoplastic surgery and quadrantectomy in breast cancer

Navneet Kaur, Jean Yves Petit, Mario Rietjens, Fausto Maffini, Alberto Luini, Giovanna Gatti, Pier Carlo Rey, Cicero Urban, Francesca De Lorenzi

Research output: Contribution to journalArticle

Abstract

Background: Oncoplastic surgery for breast cancer is a novel concept that combines a plastic surgical procedure with breast-conserving treatment to improve the final cosmetic results. The aim of this study was to evaluate the oncological safety of oncoplastic procedures by studying the status of the surgical margins of the excised tumor specimen in comparison with standard quadrantectomies. Methods: Thirty consecutive breast cancer patients undergoing oncoplastic surgery (group 1) and 30 patients undergoing standard quadrantectomy (group 2) were prospectively studied with regard to the stage of breast cancer, the surgical procedures performed, the volume of breast tissue excised, and the histopathology of the tumor specimen, with specific details on surgical margins. Results: Patients who underwent oncoplastic surgery (group 1) were younger (mean age, 48.73 years) than patients who had a classic quadrantectomy (group 2; mean age, 55.76 years; P = .022). The mean volume of the excised specimen in group 1 was 200.18 cm3, compared with 117.55 cm 3 in group 2 (P = .016). Surgical margins were negative in 25 cases out of 30 in group 1 and 17 out of 30 in group 2 (P = .05). The average length of the surgical margin was 8.5 mm in group 1 and 6.5 mm in group 2, but the difference was not statistically significant (P = .074). Conclusions: Oncoplastic surgery adds to the oncological safety of breast-conserving treatment because a larger volume of breast tissue can be excised and a wider negative margin can be obtained. It is especially indicated for large tumors, for which standard breast-conserving treatment has a high probability of leaving positive margins.

Original languageEnglish
Pages (from-to)539-545
Number of pages7
JournalAnnals of Surgical Oncology
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Breast
Breast Neoplasms
Safety
Neoplasms
Cosmetics
Therapeutics
Margins of Excision

Keywords

  • Breast cancer
  • Oncoplastic surgery
  • Plastic surgery
  • Quadrantectomy
  • Surgical margins

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Comparative study of surgical margins in oncoplastic surgery and quadrantectomy in breast cancer. / Kaur, Navneet; Petit, Jean Yves; Rietjens, Mario; Maffini, Fausto; Luini, Alberto; Gatti, Giovanna; Rey, Pier Carlo; Urban, Cicero; De Lorenzi, Francesca.

In: Annals of Surgical Oncology, Vol. 12, No. 7, 07.2005, p. 539-545.

Research output: Contribution to journalArticle

@article{a9f9666dfe5243c08ca7913138ba006e,
title = "Comparative study of surgical margins in oncoplastic surgery and quadrantectomy in breast cancer",
abstract = "Background: Oncoplastic surgery for breast cancer is a novel concept that combines a plastic surgical procedure with breast-conserving treatment to improve the final cosmetic results. The aim of this study was to evaluate the oncological safety of oncoplastic procedures by studying the status of the surgical margins of the excised tumor specimen in comparison with standard quadrantectomies. Methods: Thirty consecutive breast cancer patients undergoing oncoplastic surgery (group 1) and 30 patients undergoing standard quadrantectomy (group 2) were prospectively studied with regard to the stage of breast cancer, the surgical procedures performed, the volume of breast tissue excised, and the histopathology of the tumor specimen, with specific details on surgical margins. Results: Patients who underwent oncoplastic surgery (group 1) were younger (mean age, 48.73 years) than patients who had a classic quadrantectomy (group 2; mean age, 55.76 years; P = .022). The mean volume of the excised specimen in group 1 was 200.18 cm3, compared with 117.55 cm 3 in group 2 (P = .016). Surgical margins were negative in 25 cases out of 30 in group 1 and 17 out of 30 in group 2 (P = .05). The average length of the surgical margin was 8.5 mm in group 1 and 6.5 mm in group 2, but the difference was not statistically significant (P = .074). Conclusions: Oncoplastic surgery adds to the oncological safety of breast-conserving treatment because a larger volume of breast tissue can be excised and a wider negative margin can be obtained. It is especially indicated for large tumors, for which standard breast-conserving treatment has a high probability of leaving positive margins.",
keywords = "Breast cancer, Oncoplastic surgery, Plastic surgery, Quadrantectomy, Surgical margins",
author = "Navneet Kaur and Petit, {Jean Yves} and Mario Rietjens and Fausto Maffini and Alberto Luini and Giovanna Gatti and Rey, {Pier Carlo} and Cicero Urban and {De Lorenzi}, Francesca",
year = "2005",
month = "7",
doi = "10.1245/ASO.2005.12.046",
language = "English",
volume = "12",
pages = "539--545",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York LLC",
number = "7",

}

TY - JOUR

T1 - Comparative study of surgical margins in oncoplastic surgery and quadrantectomy in breast cancer

AU - Kaur, Navneet

AU - Petit, Jean Yves

AU - Rietjens, Mario

AU - Maffini, Fausto

AU - Luini, Alberto

AU - Gatti, Giovanna

AU - Rey, Pier Carlo

AU - Urban, Cicero

AU - De Lorenzi, Francesca

PY - 2005/7

Y1 - 2005/7

N2 - Background: Oncoplastic surgery for breast cancer is a novel concept that combines a plastic surgical procedure with breast-conserving treatment to improve the final cosmetic results. The aim of this study was to evaluate the oncological safety of oncoplastic procedures by studying the status of the surgical margins of the excised tumor specimen in comparison with standard quadrantectomies. Methods: Thirty consecutive breast cancer patients undergoing oncoplastic surgery (group 1) and 30 patients undergoing standard quadrantectomy (group 2) were prospectively studied with regard to the stage of breast cancer, the surgical procedures performed, the volume of breast tissue excised, and the histopathology of the tumor specimen, with specific details on surgical margins. Results: Patients who underwent oncoplastic surgery (group 1) were younger (mean age, 48.73 years) than patients who had a classic quadrantectomy (group 2; mean age, 55.76 years; P = .022). The mean volume of the excised specimen in group 1 was 200.18 cm3, compared with 117.55 cm 3 in group 2 (P = .016). Surgical margins were negative in 25 cases out of 30 in group 1 and 17 out of 30 in group 2 (P = .05). The average length of the surgical margin was 8.5 mm in group 1 and 6.5 mm in group 2, but the difference was not statistically significant (P = .074). Conclusions: Oncoplastic surgery adds to the oncological safety of breast-conserving treatment because a larger volume of breast tissue can be excised and a wider negative margin can be obtained. It is especially indicated for large tumors, for which standard breast-conserving treatment has a high probability of leaving positive margins.

AB - Background: Oncoplastic surgery for breast cancer is a novel concept that combines a plastic surgical procedure with breast-conserving treatment to improve the final cosmetic results. The aim of this study was to evaluate the oncological safety of oncoplastic procedures by studying the status of the surgical margins of the excised tumor specimen in comparison with standard quadrantectomies. Methods: Thirty consecutive breast cancer patients undergoing oncoplastic surgery (group 1) and 30 patients undergoing standard quadrantectomy (group 2) were prospectively studied with regard to the stage of breast cancer, the surgical procedures performed, the volume of breast tissue excised, and the histopathology of the tumor specimen, with specific details on surgical margins. Results: Patients who underwent oncoplastic surgery (group 1) were younger (mean age, 48.73 years) than patients who had a classic quadrantectomy (group 2; mean age, 55.76 years; P = .022). The mean volume of the excised specimen in group 1 was 200.18 cm3, compared with 117.55 cm 3 in group 2 (P = .016). Surgical margins were negative in 25 cases out of 30 in group 1 and 17 out of 30 in group 2 (P = .05). The average length of the surgical margin was 8.5 mm in group 1 and 6.5 mm in group 2, but the difference was not statistically significant (P = .074). Conclusions: Oncoplastic surgery adds to the oncological safety of breast-conserving treatment because a larger volume of breast tissue can be excised and a wider negative margin can be obtained. It is especially indicated for large tumors, for which standard breast-conserving treatment has a high probability of leaving positive margins.

KW - Breast cancer

KW - Oncoplastic surgery

KW - Plastic surgery

KW - Quadrantectomy

KW - Surgical margins

UR - http://www.scopus.com/inward/record.url?scp=21244500229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21244500229&partnerID=8YFLogxK

U2 - 10.1245/ASO.2005.12.046

DO - 10.1245/ASO.2005.12.046

M3 - Article

C2 - 15889210

AN - SCOPUS:21244500229

VL - 12

SP - 539

EP - 545

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 7

ER -