Comparative study on the influence of bases on (3-N-[11C]methyl)spiperone synthesis

Claudio Pascali, Ren Iwata, Tatsuo Ido

Research output: Contribution to journalArticle

Abstract

A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.

Original languageEnglish
Pages (from-to)1526-1528
Number of pages3
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume43
Issue number12
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Radiation

Fingerprint Dive into the research topics of 'Comparative study on the influence of bases on (3-N-[<sup>11</sup>C]methyl)spiperone synthesis'. Together they form a unique fingerprint.

  • Cite this