TY - JOUR
T1 - Comparative study on the influence of bases on (3-N-[11C]methyl)spiperone synthesis
AU - Pascali, Claudio
AU - Iwata, Ren
AU - Ido, Tatsuo
PY - 1992
Y1 - 1992
N2 - A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.
AB - A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.
UR - http://www.scopus.com/inward/record.url?scp=0026469086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026469086&partnerID=8YFLogxK
U2 - 10.1016/0883-2889(92)90185-H
DO - 10.1016/0883-2889(92)90185-H
M3 - Article
AN - SCOPUS:0026469086
VL - 43
SP - 1526
EP - 1528
JO - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
JF - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
SN - 0883-2889
IS - 12
ER -