Comparing 3T T1-weighted sequences in identifying hyperintense punctate lesions in preterm neonates

D. Tortora, V. Panara, P. A. Mattei, A. Tartaro, R. Salomone, S. Domizio, A. R. Cotroneo, Massimo Caulo

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: The loss of contrast on T1-weighted MR images at 3T may affect the detection of hyperintense punctate lesions indicative of periventricular leukomalacia in preterm neonates. The aim of the present study was to determine which 3T T1-weighted sequence identified the highest number of hyperintense punctate lesions and to explore the relationship between the number of hyperintense punctate lesions and clinical outcome. MATERIALS AND METHODS: The presence of hyperintense punctate lesions was retrospectively evaluated in 200 consecutive preterm neonates on 4 axial T1-weighted sequences: 3-mm inversion recovery and spin-echo and 1- and 3-mm reformatted 3D-fast-field echo. Statistically significant differences in the number of hyperintense punctate lesions were evaluated by using a linear mixed-model analysis. Logistic regression analysis was used to assess the relation between the number of hyperintense punctate lesions and neuromotor outcome at 3 months. RESULTS: Thirty-one neonates had at least 1 hyperintense punctate lesion indicative of periventricular leukomalacia in at least 1 of the 4 sequences. The 1-mm axial reformatted 3D-fast-field echo sequence identified the greatest number of hyperintense punctate lesions (P <.001). No statistically significant differences were found among the 3-mm T1-weighted sequences. The greater number of hyperintense punctate lesions detected by the 1-mm reformatted T1 3D-fast-field echo sequence in the central region of the brain was associated with a worse clinical outcome. CONCLUSIONS: At 3T, the 1-mm axial reformatted T1 3D-fast-field echo sequence identified the greatest number of hyperintense punctate lesions in the central region of preterm neonate brains, and this number was associated with neuromotor outcome.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Periventricular Leukomalacia
Brain
Linear Models
Logistic Models
Regression Analysis
3-monoiodothyronine

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Comparing 3T T1-weighted sequences in identifying hyperintense punctate lesions in preterm neonates. / Tortora, D.; Panara, V.; Mattei, P. A.; Tartaro, A.; Salomone, R.; Domizio, S.; Cotroneo, A. R.; Caulo, Massimo.

In: American Journal of Neuroradiology, Vol. 36, No. 3, 01.03.2015, p. 581-586.

Research output: Contribution to journalArticle

Tortora, D, Panara, V, Mattei, PA, Tartaro, A, Salomone, R, Domizio, S, Cotroneo, AR & Caulo, M 2015, 'Comparing 3T T1-weighted sequences in identifying hyperintense punctate lesions in preterm neonates', American Journal of Neuroradiology, vol. 36, no. 3, pp. 581-586. https://doi.org/10.3174/ajnr.A4144
Tortora, D. ; Panara, V. ; Mattei, P. A. ; Tartaro, A. ; Salomone, R. ; Domizio, S. ; Cotroneo, A. R. ; Caulo, Massimo. / Comparing 3T T1-weighted sequences in identifying hyperintense punctate lesions in preterm neonates. In: American Journal of Neuroradiology. 2015 ; Vol. 36, No. 3. pp. 581-586.
@article{8cd4d02d4d5d45269c6fb2111077f23b,
title = "Comparing 3T T1-weighted sequences in identifying hyperintense punctate lesions in preterm neonates",
abstract = "BACKGROUND AND PURPOSE: The loss of contrast on T1-weighted MR images at 3T may affect the detection of hyperintense punctate lesions indicative of periventricular leukomalacia in preterm neonates. The aim of the present study was to determine which 3T T1-weighted sequence identified the highest number of hyperintense punctate lesions and to explore the relationship between the number of hyperintense punctate lesions and clinical outcome. MATERIALS AND METHODS: The presence of hyperintense punctate lesions was retrospectively evaluated in 200 consecutive preterm neonates on 4 axial T1-weighted sequences: 3-mm inversion recovery and spin-echo and 1- and 3-mm reformatted 3D-fast-field echo. Statistically significant differences in the number of hyperintense punctate lesions were evaluated by using a linear mixed-model analysis. Logistic regression analysis was used to assess the relation between the number of hyperintense punctate lesions and neuromotor outcome at 3 months. RESULTS: Thirty-one neonates had at least 1 hyperintense punctate lesion indicative of periventricular leukomalacia in at least 1 of the 4 sequences. The 1-mm axial reformatted 3D-fast-field echo sequence identified the greatest number of hyperintense punctate lesions (P <.001). No statistically significant differences were found among the 3-mm T1-weighted sequences. The greater number of hyperintense punctate lesions detected by the 1-mm reformatted T1 3D-fast-field echo sequence in the central region of the brain was associated with a worse clinical outcome. CONCLUSIONS: At 3T, the 1-mm axial reformatted T1 3D-fast-field echo sequence identified the greatest number of hyperintense punctate lesions in the central region of preterm neonate brains, and this number was associated with neuromotor outcome.",
author = "D. Tortora and V. Panara and Mattei, {P. A.} and A. Tartaro and R. Salomone and S. Domizio and Cotroneo, {A. R.} and Massimo Caulo",
year = "2015",
month = "3",
day = "1",
doi = "10.3174/ajnr.A4144",
language = "English",
volume = "36",
pages = "581--586",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "3",

}

TY - JOUR

T1 - Comparing 3T T1-weighted sequences in identifying hyperintense punctate lesions in preterm neonates

AU - Tortora, D.

AU - Panara, V.

AU - Mattei, P. A.

AU - Tartaro, A.

AU - Salomone, R.

AU - Domizio, S.

AU - Cotroneo, A. R.

AU - Caulo, Massimo

PY - 2015/3/1

Y1 - 2015/3/1

N2 - BACKGROUND AND PURPOSE: The loss of contrast on T1-weighted MR images at 3T may affect the detection of hyperintense punctate lesions indicative of periventricular leukomalacia in preterm neonates. The aim of the present study was to determine which 3T T1-weighted sequence identified the highest number of hyperintense punctate lesions and to explore the relationship between the number of hyperintense punctate lesions and clinical outcome. MATERIALS AND METHODS: The presence of hyperintense punctate lesions was retrospectively evaluated in 200 consecutive preterm neonates on 4 axial T1-weighted sequences: 3-mm inversion recovery and spin-echo and 1- and 3-mm reformatted 3D-fast-field echo. Statistically significant differences in the number of hyperintense punctate lesions were evaluated by using a linear mixed-model analysis. Logistic regression analysis was used to assess the relation between the number of hyperintense punctate lesions and neuromotor outcome at 3 months. RESULTS: Thirty-one neonates had at least 1 hyperintense punctate lesion indicative of periventricular leukomalacia in at least 1 of the 4 sequences. The 1-mm axial reformatted 3D-fast-field echo sequence identified the greatest number of hyperintense punctate lesions (P <.001). No statistically significant differences were found among the 3-mm T1-weighted sequences. The greater number of hyperintense punctate lesions detected by the 1-mm reformatted T1 3D-fast-field echo sequence in the central region of the brain was associated with a worse clinical outcome. CONCLUSIONS: At 3T, the 1-mm axial reformatted T1 3D-fast-field echo sequence identified the greatest number of hyperintense punctate lesions in the central region of preterm neonate brains, and this number was associated with neuromotor outcome.

AB - BACKGROUND AND PURPOSE: The loss of contrast on T1-weighted MR images at 3T may affect the detection of hyperintense punctate lesions indicative of periventricular leukomalacia in preterm neonates. The aim of the present study was to determine which 3T T1-weighted sequence identified the highest number of hyperintense punctate lesions and to explore the relationship between the number of hyperintense punctate lesions and clinical outcome. MATERIALS AND METHODS: The presence of hyperintense punctate lesions was retrospectively evaluated in 200 consecutive preterm neonates on 4 axial T1-weighted sequences: 3-mm inversion recovery and spin-echo and 1- and 3-mm reformatted 3D-fast-field echo. Statistically significant differences in the number of hyperintense punctate lesions were evaluated by using a linear mixed-model analysis. Logistic regression analysis was used to assess the relation between the number of hyperintense punctate lesions and neuromotor outcome at 3 months. RESULTS: Thirty-one neonates had at least 1 hyperintense punctate lesion indicative of periventricular leukomalacia in at least 1 of the 4 sequences. The 1-mm axial reformatted 3D-fast-field echo sequence identified the greatest number of hyperintense punctate lesions (P <.001). No statistically significant differences were found among the 3-mm T1-weighted sequences. The greater number of hyperintense punctate lesions detected by the 1-mm reformatted T1 3D-fast-field echo sequence in the central region of the brain was associated with a worse clinical outcome. CONCLUSIONS: At 3T, the 1-mm axial reformatted T1 3D-fast-field echo sequence identified the greatest number of hyperintense punctate lesions in the central region of preterm neonate brains, and this number was associated with neuromotor outcome.

UR - http://www.scopus.com/inward/record.url?scp=84924859726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924859726&partnerID=8YFLogxK

U2 - 10.3174/ajnr.A4144

DO - 10.3174/ajnr.A4144

M3 - Article

C2 - 25376807

AN - SCOPUS:84924859726

VL - 36

SP - 581

EP - 586

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 3

ER -