Comparing core needle to surgical biopsies in breast cancer for cell kinetic and ploidy studies

Maria Grazia Daidone, Sergio Orefice, Marinella Mastore, Giuseppe Santoro, Bruno Salvadori, Rosella Silvestrini

Research output: Contribution to journalArticlepeer-review

Abstract

The evaluability and reliability of proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) and ploidy determinations on core needle biopsies were compared with those obtained on surgical material from the same breast cancers. The evaluability of3H-TdR LI on core needle biopsies was markedly lower than that on surgical material (53% vs 100%), and the association between3H-TdR LI values in the 16 cases with both evaluable determinations was poor (rs=0.45). Conversely, determinations of ploidy on core needle biopsy and surgical material provided superimposable results, in terms of evaluability (91% vs 100%) and reliability (rs=0.99). Further efforts are needed to improve sampling procedures for a reliable assessment of biological markers.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalBreast Cancer Research and Treatment
Volume19
Issue number1
DOIs
Publication statusPublished - Sep 1991

Keywords

  • breast cancer
  • cell proliferation
  • core needle biopsy
  • ploidy
  • thymidine labeling index

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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