Comparing core needle to surgical biopsies in breast cancer for cell kinetic and ploidy studies

Maria Grazia Daidone; Sergio Orefice; Marinella Mastore; Giuseppe Santoro; Bruno Salvadori; Rosella Silvestrini

doi:10.1007/BF01975202

Comparing core needle to surgical biopsies in breast cancer for cell kinetic and ploidy studies

Maria Grazia Daidone, Sergio Orefice, Marinella Mastore, Giuseppe Santoro, Bruno Salvadori, Rosella Silvestrini

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The evaluability and reliability of proliferative activity (expressed as³H-thymidine labeling index,³H-TdR LI) and ploidy determinations on core needle biopsies were compared with those obtained on surgical material from the same breast cancers. The evaluability of³H-TdR LI on core needle biopsies was markedly lower than that on surgical material (53% vs 100%), and the association between³H-TdR LI values in the 16 cases with both evaluable determinations was poor (r_s=0.45). Conversely, determinations of ploidy on core needle biopsy and surgical material provided superimposable results, in terms of evaluability (91% vs 100%) and reliability (r_s=0.99). Further efforts are needed to improve sampling procedures for a reliable assessment of biological markers.

Original language	English
Pages (from-to)	33-37
Number of pages	5
Journal	Breast Cancer Research and Treatment
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/BF01975202
Publication status	Published - Sep 1991

Keywords

breast cancer
cell proliferation
core needle biopsy
ploidy
thymidine labeling index

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/BF01975202

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title = "Comparing core needle to surgical biopsies in breast cancer for cell kinetic and ploidy studies",

abstract = "The evaluability and reliability of proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) and ploidy determinations on core needle biopsies were compared with those obtained on surgical material from the same breast cancers. The evaluability of3H-TdR LI on core needle biopsies was markedly lower than that on surgical material (53% vs 100%), and the association between3H-TdR LI values in the 16 cases with both evaluable determinations was poor (rs=0.45). Conversely, determinations of ploidy on core needle biopsy and surgical material provided superimposable results, in terms of evaluability (91% vs 100%) and reliability (rs=0.99). Further efforts are needed to improve sampling procedures for a reliable assessment of biological markers.",

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AU - Daidone, Maria Grazia

AU - Orefice, Sergio

AU - Mastore, Marinella

AU - Santoro, Giuseppe

AU - Salvadori, Bruno

AU - Silvestrini, Rosella

PY - 1991/9

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N2 - The evaluability and reliability of proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) and ploidy determinations on core needle biopsies were compared with those obtained on surgical material from the same breast cancers. The evaluability of3H-TdR LI on core needle biopsies was markedly lower than that on surgical material (53% vs 100%), and the association between3H-TdR LI values in the 16 cases with both evaluable determinations was poor (rs=0.45). Conversely, determinations of ploidy on core needle biopsy and surgical material provided superimposable results, in terms of evaluability (91% vs 100%) and reliability (rs=0.99). Further efforts are needed to improve sampling procedures for a reliable assessment of biological markers.

AB - The evaluability and reliability of proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) and ploidy determinations on core needle biopsies were compared with those obtained on surgical material from the same breast cancers. The evaluability of3H-TdR LI on core needle biopsies was markedly lower than that on surgical material (53% vs 100%), and the association between3H-TdR LI values in the 16 cases with both evaluable determinations was poor (rs=0.45). Conversely, determinations of ploidy on core needle biopsy and surgical material provided superimposable results, in terms of evaluability (91% vs 100%) and reliability (rs=0.99). Further efforts are needed to improve sampling procedures for a reliable assessment of biological markers.

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